Valid surrogate endpoints that are clinically meaningful require compliance with the Prentice criterion: (i) the surrogate needs to correlate with its true clinical endpoint and (ii) the surrogate/clinical endpoint correlation needs to be independent from the treatment type applied. This means that for sealant retention to be a valid surrogate for caries prevention the material retention-loss risk should be directly associated with the caries risk and that such association holds true regardless whether the sealant was placed e.g. with composite resin or glass-ionomer. Our findings show a direct association for resin (but with only a low adjusted R2 = 0.28) but not for glass-ionomer sealants and that the ratio of retention-loss risk to the risk of caries on sealed tooth surfaces was not sealant material independent.
Mickenautsch, S. & YENGOPAL, V (2019). Complete clinical retention of sealant materials should not be contemplated as cut-off for clinical success. Afribary. Retrieved from https://track.afribary.com/works/complete-clinical-retention-of-sealant-materials-should-not-be-contemplated-as-cut-off-for-clinical-success
Mickenautsch, Steffen, and Veeresamy YENGOPAL "Complete clinical retention of sealant materials should not be contemplated as cut-off for clinical success" Afribary. Afribary, 26 May. 2019, https://track.afribary.com/works/complete-clinical-retention-of-sealant-materials-should-not-be-contemplated-as-cut-off-for-clinical-success. Accessed 25 Dec. 2024.
Mickenautsch, Steffen, and Veeresamy YENGOPAL . "Complete clinical retention of sealant materials should not be contemplated as cut-off for clinical success". Afribary, Afribary, 26 May. 2019. Web. 25 Dec. 2024. < https://track.afribary.com/works/complete-clinical-retention-of-sealant-materials-should-not-be-contemplated-as-cut-off-for-clinical-success >.
Mickenautsch, Steffen and YENGOPAL, Veeresamy . "Complete clinical retention of sealant materials should not be contemplated as cut-off for clinical success" Afribary (2019). Accessed December 25, 2024. https://track.afribary.com/works/complete-clinical-retention-of-sealant-materials-should-not-be-contemplated-as-cut-off-for-clinical-success