Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum

Abstract

Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA and inefficient erythropoiesis, a central pathogenic feature of SMA, are only partially understood. Methods We performed a pilot Genome-wide Association Study (GWAS) on children with Plasmodium falciparum. The GWAS was performed using the Illumina® Infinium® HD Super Assay in conjunction with Illumina’s® Human Omni2.5-8v1 BeadChip (with > 2.45 M markers). Data were analyzed using single SNP logistic regression analysis with an additive model of inheritance controlling for covariates. Results from our pilot global genomics study identified that variation in interleukin (IL)-7 was associated with enhanced risk of SMA. To validate this finding, we investigated the relationship between genotypes and/or haplotypes of two single nucleotide polymorphisms (SNPs) in IL7 [72194 T/C and − 2440 A/G] and susceptibility to both SMA and inefficient erythropoiesis [i.e., reticulocyte production index (RPI)

Subscribe to access this work and thousands more

Report

Subscribe & Access

Overall Rating

0

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

APA

E., K (2024). Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum. Afribary. Retrieved from https://track.afribary.com/works/genetic-variation-in-interleukin-7-is-associated-with-a-reduced-erythropoietic-response-in-kenyan-children-infected-with-plasmodium-falciparum

MLA 8th

E., Kisia "Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum" Afribary. Afribary, 04 Jun. 2024, https://track.afribary.com/works/genetic-variation-in-interleukin-7-is-associated-with-a-reduced-erythropoietic-response-in-kenyan-children-infected-with-plasmodium-falciparum. Accessed 05 Nov. 2024.

MLA7

E., Kisia . "Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum". Afribary, Afribary, 04 Jun. 2024. Web. 05 Nov. 2024. < https://track.afribary.com/works/genetic-variation-in-interleukin-7-is-associated-with-a-reduced-erythropoietic-response-in-kenyan-children-infected-with-plasmodium-falciparum >.

Chicago

E., Kisia . "Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum" Afribary (2024). Accessed November 05, 2024. https://track.afribary.com/works/genetic-variation-in-interleukin-7-is-associated-with-a-reduced-erythropoietic-response-in-kenyan-children-infected-with-plasmodium-falciparum

Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum

0

Document Details

Related Works

Probing The Trans-Sialidase Activity Of The Neuraminidase Derived From Human Influenza A (H3n2) Virus

Molecular detection of Leishmania donovani, Leishmania major, and Trypanosoma species in Sergentomyia squamipleuris sand flies from a visceral leishmaniasis focus in Merti sub-County, eastern

Molecular characterization of Plasmodium falciparum PHISTb proteins as potential targets of naturally-acquired immunity against malaria [version 2; peer review: 3 approved with reservations]

Molecular characterization of Trypanosoma vivax in tsetse flies confirms the presence of the virulent Tvv4 genotype in Kenya: Potential implications for the control of trypanosomiasis in Shim

Simple Sequence Repeat (SSR) Genetic Linkage Map of D Genome Diploid Cotton Derived from an Interspecific Cross between Gossypium davidsonii and Gossypium klotzschianum

In-silico analysis of potent Mosquirix vaccine adjuvant leads