ABSTRACT
The most common complaint among patients in the out-patient clinics are sore
throat, and the most frequent diagnosis is chronic non-specific pharyngitis. Chronic
pharyngitis is still controversial. Helicobacter pylori, besides being the major cause
of chronic gastritis, might also be involved in playing role in the upper respiratory
tract infection.
This study aimed to determine the relationship between H. pylori infection and
throat infection and its possible role in the etiology and pathogenesis of bacterial
pharyngitis and tonsillitis. This was achieved by determination of antibody titer in
patients with H. pylori infection. Not only that but also the presence of Streptococcus
pyogenes, the main pathogen involved in throat infection, was investigated via
culturing, and the assessment of the relationship between H. pylori infection and the
aggravation of the sore throat infection.
From volunteers questionnaire data and three hundred and seven samples of throat
swabs from tonsils and aurophaynx were collected and cultured from H. pylori
seropositive and apparently healthy people. Conventional bacteriological methods
were applied for isolation of bacteria among which is Streptococcus pyogenes.
Pathogenic sore throat causing bacteria were isolated from 74% tonsils and 76.3%
pharynx of whole samples. 78.2% individuals had pathogenic bacteria in tonsil and
auropharynx, but clinical respiratory signs were observed only in 9.7% of the whole
individuals. Streptococcus pyogenes was the most predominant bacteria, PCR was
conducted to confirm their identity, and dependingly 14..% of them were detected
by PCR using spy1258 primer.Three hundred and seven blood samples were also collected from the same participants correspondingly for the determination of Anti-Helicobacter pylori IgG and IgA measurement. So that, IgG titer was found to be significantly correlated with IgA ratio (at 99% confident interval, 2 tailed). In this study H. pylori positive cases were found to be significantly correlated with upper digestive tract signs (at 99% confident interval, 2 tailed). Besides the upper digestive tract illness signs were correlated with sore throat (at 95% confident interval, 2 tailed).
This study revealed a significant correlation between H. pylori infection and sore
throat, theoretically due to the accompanied laryngeopharyngeal reflux which in
turn reduces the throat pH enhancing the condition for S. pyogenes and other acidic
pH tolerant pathogens. The results showed that the prevalence of H. pylori infection
in our population is quite high (88.2%), this infer that the infection is elevated in
Sudan during last years and expected to keep increasing unless further studies and
solutions applied. S. pyogenes has been found to be the most causative agent of
bacterial sore throat in Sudan whether it is related to H. pylori infection or not. In
spite of commonly using ICT rapid test for H. pylori diagnosis in Sudanese labs and
Hospitals, our study revealed the ICT antibody-based is not very reliable.
It is recommended to search the correlation between H. pylori positive infection and
viral throat infection because it is also frequent than bacterial throat infection.
Testing this research hypothesis should be followed depending on isolation of H.
pylori, instead of conducting serological tests, with the isolation of S. pyogenes. The
reuse of same antibiotics against H. pylori must be eschewed to avoid bacterial
resistance. Such resistance is common in patients who had previous antibiotic
treatment. Humoral immunity does not protect against H. pylori cellular does protect
(Kuster et al, 2009). Further research in cellular immunity of H. pylori is needed. It
is essential to develop a new PCR primer, specific for Streptococcus pyogenes and
sensitive for its all strains to replace spy1258 primer. ICT method of H infection diagnosis should be avoided and replaced by more trusted methods.
Eldin, H (2021). Relationship Between Helicobacter Pylori Seropositive Patients And Throat Infection. Afribary. Retrieved from https://track.afribary.com/works/relationship-between-helicobacter-pylori-seropositive-patients-and-throat-infection
Eldin, Hiba "Relationship Between Helicobacter Pylori Seropositive Patients And Throat Infection" Afribary. Afribary, 19 May. 2021, https://track.afribary.com/works/relationship-between-helicobacter-pylori-seropositive-patients-and-throat-infection. Accessed 24 Dec. 2024.
Eldin, Hiba . "Relationship Between Helicobacter Pylori Seropositive Patients And Throat Infection". Afribary, Afribary, 19 May. 2021. Web. 24 Dec. 2024. < https://track.afribary.com/works/relationship-between-helicobacter-pylori-seropositive-patients-and-throat-infection >.
Eldin, Hiba . "Relationship Between Helicobacter Pylori Seropositive Patients And Throat Infection" Afribary (2021). Accessed December 24, 2024. https://track.afribary.com/works/relationship-between-helicobacter-pylori-seropositive-patients-and-throat-infection