ABSTRACT Background: Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus (SLE) and is associated with end-stage renal disease, need for renal replacement therapy and death. There is no African data comparing the efficacy or outcome of patients managed with Mycophenolate mofetil (MMF) or intravenous (IV) cyclophosphamide (CYC) during induction of proliferative LN. Objectives: The study aimed to assess treatment response after induction therapy with MMF or IV CYC in patients with proliferative LN at a single centre in South Africa. Methods: We performed a retrospective review of records of patients with biopsy proven proliferative LN diagnosed and treated with either MMF or IV CYC at Groote Schuur Hospital (GSH), Cape Town, South Africa. We assessed remission status, adverse events and death between the two groups. Results: Patients treated with IVCYC and MMF had a mean age of 30.3 ± 11.2 and 27.0 ± 6.9 years respectively, (p=0.23). At baseline, the IVCYC group had significantly higher mean arterial pressure, serum creatinine and glomerular crescents (p
Africa, P. & Sogayise, P (2021). Retrospective Comparison Of Cyclophosphamide And Mycophenolate Mofetil In Lupus Nephritis At Groote Schuur Hospital Nephrology Unit. Afribary. Retrieved from https://track.afribary.com/works/retrospective-comparison-of-cyclophosphamide-and-mycophenolate-mofetil-in-lupus-nephritis-at-groote-schuur-hospital-nephrology-unit
Africa, PSN, and Phelisa Sogayise "Retrospective Comparison Of Cyclophosphamide And Mycophenolate Mofetil In Lupus Nephritis At Groote Schuur Hospital Nephrology Unit" Afribary. Afribary, 19 Apr. 2021, https://track.afribary.com/works/retrospective-comparison-of-cyclophosphamide-and-mycophenolate-mofetil-in-lupus-nephritis-at-groote-schuur-hospital-nephrology-unit. Accessed 27 Nov. 2024.
Africa, PSN, and Phelisa Sogayise . "Retrospective Comparison Of Cyclophosphamide And Mycophenolate Mofetil In Lupus Nephritis At Groote Schuur Hospital Nephrology Unit". Afribary, Afribary, 19 Apr. 2021. Web. 27 Nov. 2024. < https://track.afribary.com/works/retrospective-comparison-of-cyclophosphamide-and-mycophenolate-mofetil-in-lupus-nephritis-at-groote-schuur-hospital-nephrology-unit >.
Africa, PSN and Sogayise, Phelisa . "Retrospective Comparison Of Cyclophosphamide And Mycophenolate Mofetil In Lupus Nephritis At Groote Schuur Hospital Nephrology Unit" Afribary (2021). Accessed November 27, 2024. https://track.afribary.com/works/retrospective-comparison-of-cyclophosphamide-and-mycophenolate-mofetil-in-lupus-nephritis-at-groote-schuur-hospital-nephrology-unit