Pro- and anti-inflammatory cytokines mediate the progression of severe anemia in malaria-infected children: A prospective study
Background Severe Plasmodium falciparum malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti-inflammatory cytokines is associated with malaria progression. This study evaluated circulating levels of selected inflammatory cytokines among malaria-infected children in Ghana. Methods This case-control study was conducted at Tamale Teaching Hospital, Ghana. One hundred and twenty children with malaria and 60 ...
Investigating hemolysis, elevated liver enzymes and low platelet count in preeclampsia: A case‐control study in Ghana
Background and Aims: Preeclampsia poses a heightened risk for women, particularly in the development of hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome, leading to adverse outcomes for both mothers and newborns. The incidence of HELLP syndrome tends to be notably higher among women with preeclampsia compared with those with normotensive pregnancies. However, there is a dearth of research on the frequency of HELLP syndrome within the context of preeclampsia specifically...
Maternal hepatitis B status and Sex at birth: A cross-sectional study in a Ghanaian population
Maternal carrier status of hepatitis B has been associated with excess sons while maternal immunity to it has been associated with excess daughters at birth. However, the proportion of males at birth (sex ratio) is relatively low in Sub-Saharan Africa despite the relatively high prevalence of hepatitis B. However, no known study has tested this hypothesis in the Ghanaian population, hence the aim of the study. The study was cross-sectional between January and September 2023 at the Tamale Cent...
Maternal hepatitis B status and Sex at birth: A cross-sectional study in a Ghanaian population
Maternal carrier status of hepatitis B has been associated with excess sons while maternal immunity to it has been associated with excess daughters at birth. However, the proportion of males at birth (sex ratio) is relatively low in Sub-Saharan Africa despite the relatively high prevalence of hepatitis B. However, no known study has tested this hypothesis in the Ghanaian population, hence the aim of the study. The study was cross-sectional between January and September 2023 at the Tamale Cent...
Assessing the reliability and accuracy of sex estimation models utilizing sternal morphometry derived from computed tomography in the Ghanaian population
Sex estimation models are specific to populations and cannot be generalized due to genetic and environmental variabilities. This retrospective cross-sectional study, conducted between January and September 2023 at the Tamale Teaching Hospital, included 119 (50.9 %) females and 115 (49.1 %) males aged 23–82 years. Measurements, including manubrium length (M), manubrium width (MW), sternal body length (B), combined manubrium and sternal body lengths (CL), corpus sterni width at first sternebr...
Exploring Maternal Biomarkers and Risk Factors in Preeclampsia: Insights from a Ghanaian Case-control Study
Aims: The involvement of maternal sociodemographic, obstetric, clinical, anthropometric and biochemical variables in preeclampsia has been demonstrated in previous studies. However, there are intra- and inter-population variabilities in study findings due to differences in genetic and environmental factors. This requires population-specific studies to aid the formulation of local protocols for the early detection and management of preeclampsia. Study Design: This was a case-control study Pl...
Exploring Hematological and Biochemical Disparities in Same-Sex and Opposite-Sex Females: A Cross-Sectional Twin Study in a Ghanaian Population
There are sex-dependent differences in hematological and biochemical variables in adulthood attributed to the predominant effects of testosterone in males and estrogen in females. The Twin Testosterone Transfer (TTT) hypothesis proposes that opposite-sex females may develop male-typical traits due to exposure to relatively higher levels of prenatal testosterone than same-sex females. Additionally, prenatal testosterone exposure has been suggested as a correlate of current circulating testoste...
Is sexual dimorphism in morphometric variables of the proximal femur moderated by age in adulthood? A cross-sectional study in Ghana
Ageing may impact proximal femoral morphometry in both males and females. However, it is not clear whether the observed sexual dimorphism is attributable to an ageing effect in the post-pubertal period. The potential effect of ageing on sexual dimorphism in the proximal femur is most significantly relevant for forensic and osteoarchaeological research. The study was cross-sectional and comprised 123 participants (females = 72 and males = 51), who were recorded between January 2017 and June 20...
Is sexual dimorphism in morphometric variables of the proximal femur moderated by agein adulthood? Across-sectional study in Ghana
Ageing may impact proximal femoral morphometry in both males and females. However, it is not clear whether the observed sexual dimorphism is attributable to an ageing effect in the post-pubertal period. The potential effect of ageing on sexual dimorphism in the proximal femur is most significantly relevant for forensic and osteoarchaeological research. The study was cross-sectional and comprised 123 participants (females = 72 and males = 51), who were recorded between January 2017 and June 20...
Immune checkpoint molecules B7‐1 and B7‐H1 as predictive markers of pre‐eclampsia: A case–control study in Ghana
Background/Aim: Immune tolerance in the fetal–maternal junction is maintained by a balance in the Th1/Th2 system. Th1‐type immunity is associated with pro‐inflammatory cytokines and immune checkpoint molecules (ICMs) such as B7‐H1, while Th2‐type immunity is characterized by anti‐inflammatory cytokines and ICMs such as B7‐1. Any imbalance in the Th1/Th2 immune system may lead to adverse pregnancy outcomes such as pre‐eclampsia (PE). Hitherto, the potential of serum B7‐1 and ...
Are sex differences in blood cell count and hemoglobin moderated by the 2D:4D ratio? A cross‐sectional study in a Ghanaian population
Background and Aims: There are sex differences in blood cell count and hemoglobin (HGB) in adulthood due to differences in the levels of circulating sex hormones. The second‐to‐fourth digit ratio (2D:4D) is the putative marker of prenatal hormone exposure. The 2D:4D or the right‐left difference (Dr‐l) are sexually dimorphic and are correlates of sex hormones in adulthood. The study sought to determine whether sex differences in adult blood cell count and HGB can be partly explained by...
Forensic science in Ghana: A review
The use of forensic science continues to grow across the world. In Ghana, major advancements took off in 2011, including the introduction of modern DNA profiling and the establishment of an automated fingerprint identification system. These developments have led to some positive impacts on the delivery of justice, including the exoneration of a wrongly incarcerated individual. However, a review of the policy-related aspects of forensic science shows gaps in legislation, governance, service pr...
Effects of Highly Active Antiretroviral Treatment on Complete Blood Count Parameters
Aim: This study assesses the effects of HAART on complete blood count parameters among HIV infected participants. Study Design: Case control study. Place and Methods: This study was conducted in Tamale, Ghana from August, 2016 to December, 2017. Methodology: A total of 300 HIV infected participants with ages ranging from 19–79 years, administered with HAART for at least 6 months were recruited. Pre-HAART administration (baseline) demographic and clinical information, with initial full bloo...
Hepatitis B and C Status and Associated Risk Factors among Migrant Female Head Porters [Kayayei] within La-Nkwantanang Madina Municipality, Ghana
Aim: This study was conducted to determine the knowledge, prevalence and associated risk factors of viral hepatitis among migrant female head porters (Kayayei) in La-Nkwantanang Madina municipality of the Greater Accra region, Ghana. Study Design: A descriptive cross-sectional study was conducted. Place and Duration of Study: The study was carried out at three market centers [Atima, LaNkwantanang and Madina markets] within the La-Nkwantanang Madina municipality of the Greater Accra region, Gh...
Effects of Highly Active Antiretroviral Treatment on Liver and Kidney Functions
Aim: This study assesses the effects of HAART on liver and renal functions in HIV infected individuals on HAART. Study Design: Cross sectional study. Place and Methods: This study was conducted in Tamale, Ghana from August, 2015 to November 2017. Methodology: A total of 300 HIV infected participants with ages ranging from 19 to 79 years who have been administered with HAART for at least 6 months were recruited. Pre-HAART administration (baseline) demographic and clinical information, with ini...
Doctorate
University for Development Studies
July 2018 to Present