Abstract NSAIDs and coxibs are associated with serious gastroinstestinal and cardiovascular side effects on their long term usage. Five hydrazones having chloro, methoxy, and nitro group substitutions were designed following a patent and extensive literature review. The designed compounds were evaluated in-silico for their pharmacokinetic and toxicity profile. Synthesis of the hydrazones was achieved through mechanochemistry (solvent-free) and conventional methods. Structures of the synthesiz...
The goal of this research was the discovery of newer anti-inflammatory drug. Four hydrazones with p-nitrophenyl moiety were synthesized by solvent-free and conventional synthetic methods with good to excellent yields. The synthesized hydrazones were evaluated for their anti-inflammatory activities using carrageenan-induced paw edema in mice. All the compounds indicated significant anti-inflammatory activity, demonstrating slow onset of action and longer duration of action compared to celecoxi...
The preliminary screening of phytochemical constituents of extracts of Xylopia aethiopica was evaluated. The n-hexane extract revealedthe presence of terpenoids, alkaloids, and steroids, while the presence of alkaloids, terpenoids, saponins, steroids, and phenolics was indicated in ethyl acetate extract, and the methanol extract contained tannins, flavonoids, phenolics, terpenoids, saponins, alkaloids, steroids. The medicinal property of the extracts was investigated using in-vitro antimicrob...
We designed novel p-nitrophenyl hydrazones as multi-target inhibitors of COX-2, 5-LOX, and H+/K+ ATPase in a bid to overcome side effects associated to NSAIDs and coxibs. Specifically, compounds 1-(4-nitrophenyl)-2-[(3,4,5-trimethoxyphenyl)methylidene] hydrazine (3), 4-hydroxy-2-methyl-6-[(2-(4-nitrophenyl)hydraz-1-ylidene)methyl]thiochroman-1,1-dioxide (6), 4-methoxy-2-methyl-6-[(2-(4-nitrophenyl)hydraz-1-ylidene)methyl]thiochroman-1,1-dioxide (8), 2-methyl-6-[(2-(4-nitrophenyl)hydraz-1-ylid...
