ALLELIC AND GENOTYPIC FREQUENCIES OF THE ABO BLOOD GROUP SYSTEMS AND THEIR ASSOCIATIONS WITH Helicobacter pylori INFECTION AMONG PATIENTS WITH GASTROINTESTINAL COMPLAINTS IN EJERE DISTRICT,WE

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Abstract:

Helicobacter pylori is a small, spiral-shaped bacteria that lives on the surface of the stomach and duodenum. H. pylori is closely associated with onset of diseases such as gastric ulcers, duodenal ulcers, gastritis and gastric cancers. The aim of this study was to determine the allelic and genotypic frequencies of ABO blood group system and their associations with H. pylori infection among 384 patients with gastrointestinal complaints in the Ejere and Amaro Helth Center. Stool samples were taken from all patients for detection of H. pylori antigen by chromatographic immunoassay test. The ABO blood group system was determined by hem agglutination test. A total of 128(33.3%) of the participants were H.pylori positive. The phenotypic frequencies of ABO blood group were O-type180 (46%); A-type 101(26); B-type 76(20%); and AB-type 27(7%). The allelic frequencies of ABO blood group of patients were: I A ,0.1835; I B ,0.1454 and I O ,0.6911 and the genotypic frequencieswere I A I A ,0.0341;I A I O ,0.255 3;I B I B ,0.0211;I B I O ,0.2009;I A I B ,0.0537;I O I O ,0.4776. Patients of blood type-B were more prone to H. pylori infection, 33(43%), than patients of other blood types, and patients of the AB blood type were less prone to H. pylori infection, 7 (25%), as compared with patients of other blood types. The finding of this study indicates that people with blood type-B were more susceptible to infection with H. pylori than people with other blood types. The results of this study showed that there was a significant association between A and B blood type and H. pylori infection, in which type-B has a greater tendency towards infection.

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ALLELIC AND GENOTYPIC FREQUENCIES OF THE ABO BLOOD GROUP SYSTEMS AND THEIR ASSOCIATIONS WITH Helicobacter pylori INFECTION AMONG PATIENTS WITH GASTROINTESTINAL COMPLAINTS IN EJERE DISTRICT,WE

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