ABSTRACT
Mosquitoes transmit serious human diseases, resulting into millions of deaths globally
every year. The use of synthetic insecticides to control vector mosquitoes has caused
physiological resistance and adverse environmental effects in addition to high operational
costs. Mosquito larvicidal compounds from certain plant and fungal species have been
reported. Basidiomycetes fungi are known to synthesize a wide range of bioactive secondary
metabolites. The objective of this work was to investigate the mosquito larvicidal
compound(s) from the fungus Coriolus hirsutus belonging to the basidiomycete class of
fungi. Crude extracts prepared from fermented liquid nutrient media cultures of Coriolus
hirsutus were found to exhibit activity against the larvae of Aedes aegypti species of
mosquito. The active crude extracts were further subjected to bioactivity guided fractionation
that led to the purification of two larvicidal compounds. Chemical investigation using NMR
spectroscopy and MS experiments identified the two compounds, 17–(5–hydroxy–1,5-
dimethyl-hex-3-enyl)-4,4,8,10,13-pentamethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-
tetradecahydro-3H-cyclopenta[α]phenanthren-3-ol and hexanoic acid. 17–(5–hydroxy–1,5-
dimethyl-hex-3-enyl)-4,4,8,10,13-pentamethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-
tetradecahydro-3H-cyclopenta[α]phenanthren-3-ol had an LC50 and LC90 of 147.0 ppm and
285.3 ppm at 95%CI while hexanoic acid had an LC50 and LC90 of 237.8 ppm and 393.9 ppm
at 95%CI. The two larvicidal compounds obtained from Coriolus hirsutus may constitute
important alternatives to the synthetic insecticides under the integrated vector control
strategies.
BEN, O (2021). Characterisation Of Mosquito Larvicidal Compounds From Cultures Of A Basidiomycete Coriolus Hirsutus. Afribary. Retrieved from https://track.afribary.com/works/characterisation-of-mosquito-larvicidal-compounds-from-cultures-of-a-basidiomycete-coriolus-hirsutus
BEN, OUMA "Characterisation Of Mosquito Larvicidal Compounds From Cultures Of A Basidiomycete Coriolus Hirsutus" Afribary. Afribary, 14 May. 2021, https://track.afribary.com/works/characterisation-of-mosquito-larvicidal-compounds-from-cultures-of-a-basidiomycete-coriolus-hirsutus. Accessed 24 Nov. 2024.
BEN, OUMA . "Characterisation Of Mosquito Larvicidal Compounds From Cultures Of A Basidiomycete Coriolus Hirsutus". Afribary, Afribary, 14 May. 2021. Web. 24 Nov. 2024. < https://track.afribary.com/works/characterisation-of-mosquito-larvicidal-compounds-from-cultures-of-a-basidiomycete-coriolus-hirsutus >.
BEN, OUMA . "Characterisation Of Mosquito Larvicidal Compounds From Cultures Of A Basidiomycete Coriolus Hirsutus" Afribary (2021). Accessed November 24, 2024. https://track.afribary.com/works/characterisation-of-mosquito-larvicidal-compounds-from-cultures-of-a-basidiomycete-coriolus-hirsutus