Complete Blood Count Of Sudanese Females With Breast Cancer Attending Radiation And Isotope Center In Khartoum State

Abstract

Breast cancer comprises 10.4% of all cancer incidence making it the second most type of non skin cancer and the fifth most common cause of cancer death. Breast cancer is about 100 times more common in women than in men, but survival are equal in both. it constitutes 13-35% of all female cancer. The aim of this study is to determined the Complete Blood Count in Sudanese females with breast cancer under treatment with ( Chemotherapy, Radiation or mastectomy) . This is a hospital based case control study conducted to measure complete blood count in females with breast cancer, 100 blood sample were collected from females with breast cancer compared to 20 healthy females The sample was collected in EDTA anti coagulated and tested to measure Complete blood count using automated cell counter ( sysmax KX 21) to find out ; the hemoglobin concentration (Hb), Red blood cells count (RBCs) , Packed cell volume (PCV) ,RBCs indices , White blood cells (WBCs) count and Platelet count. blood film were prepared to evaluate cell morphology. The result of this study showed that there was decrease in mean of Hb (7.66) , PCV (31.98), MCV (83.03), MCHC (27.03) and PLTs (295.88) while there were normal value in the mean of WBCs count. also, the result showed 65% of patients were anemic 27% was Microcytic Hypochromic and 35% was Normocytic Normochromic. the result showed that the mean value of Hb and PLTs in patients receiving chemotherapy was significantly reduced with P-value (0.00) while the WBCs was not affected . The result showed a significant reduction in Hb , PCV , MCV and PLTs in females with breast cancer according to breast feeding. The study concluded that the chemotherapy has a significant effect on Hb and PLTs in patients with breast cancer while WBCs was not affected . Also, there is no significant difference in Hb, WBCs and PLTs according to mastectomy of breast.