Genetic Exchange in Trypanosoma brucei: Evidence for Mating Prior to Metacyclic Stage Development

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It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken [1,2]. Both cross and self-fertilisation can take place [3,4], with the products of mating being the equivalent of F1 progeny in a Mendelian system [2,3]. Recently, analysis of a large collection of independent progeny using a series of polymorphic micro and minisatellite markers, has formally demonstrated that the allelic segregation at loci on each of the 11-megabase chromosomes conforms to ratios predicted for a classical diploid genetic system involving meiosis as well as independent assortment of markers (Continue from the attached pdf)

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Genetic Exchange in Trypanosoma brucei: Evidence for Mating Prior to Metacyclic Stage Development

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