Histological comparative studies of Vernonia amygdalina and standard livolin forte on ethanol induced hepatotoxicity in adult wistar rat

Introduction: Ethanol is one of the hepatotoxic substances that cause various hepato-degenerative

disorders which is a major concern in medical science and researches as man is regularly exposed

to it via consumption.

Methods: The aim of this study is to investigate and compare the protective effects of livolin forte

with methanolic extract of Vernonia amygdalina on the hepatic cells of ethanol induced

hepatotoxicity, 25 healthy male Wistar rats weight ranging between 150-200g were allotted into 5

groups: Normal control (Group A), ethanol control (B), combine therapy control (Group C), Livolin

forte control (Group D), and Vernonia amygdalina control (Group E) of five animals each.

Results: The macroscopic change such as nodular and abscesses were observed on the liver of

experimental animals (B, C, D and D) with regenerating changes in groups C, D and E. while the

liver architecture for the control animals appeal normal. Toxicant group B had significant higher

AST, ALT and ALP compared with the normal control group A. Similar, significant increase in serum

activities of AST, ALT and ALP were observed in group D&E compare to group C.

Conclusion: The result of this study indicated that livolin forte was better combine with Vernonia

amygdalina as a curative agent rather than livolin forte or Vernonia amygdalina alone in Rats

model.

Keywords: Hepatotoxicity; Vernonia amygdalina; alanine-aminotransferase (ALT); aspartate

aminotransferase (AST); alkaline- phosphates (ALP

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