Immunophenotype And Hepato-Biomarker Characteristics Of Hiv Infected Adults And Hematological Reference Ranges Of Children In Kisumu West Subcounty, Kenya

ABSTRACT

Proper diagnosis and management of clinical diseases requires succinct understanding of

well-established human physiological reference values. Despite the high prevalence rates

of HIV, Tuberculosis and Hepatitis infection in Kisumu area of Western Kenya, there are

no locally developed hematological values that can be used as reference values of normal

biological or homeostatic processes from which pathogenic, pathologic or pharmacologic

responses to a therapeutic intervention can be inferred. This study enrolled 1566 study

participants (1509 healthy children for hematological reference range and 57 HIV positive,

anti-retroviral therapy naive adults for immunophenotypic and hepato-biomarker

characterization. Statistical analysis was done by graphpad by use of percentiles, Mann-

Whitney test, Spearman’s correlation and Kruskall Wallis. The results of the study showed

that it was possible to establish hematology reference ranges in children below two years

and based on gender. It was noted that the total white blood cell counts, monocyte and

granulocyte absolute counts in 1 m to 6 m age groups were statistically significantly lower

than the other two age groups (p

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