Profiles Of Progesterone, Systemic Cytokines And Blood Lymphocyte Levels During Pregnancy In Women Living With Human Immunodeficiency Virus Infection In Western Kenya

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ABSTRACT

The impact of HIV infection on progesterone, systemic cytokines, and lymphocyte levels in advancing pregnancy remains unclear despite the reported abortions among HIV-infected women. Thus, the main objective of this study was to determine and compare the profiles of progesterone, systemic cytokines and blood lymphocyte counts in advancing pregnancies of HIV-infected and HIV-non-infected women population. In a longitudinal cohort study, 44 HIV-infected and 44 HIV-non-infected pregnant women were consecutively recruited at Academic Model Providing Accessible Treatment and Healthcare (AMPATH) and Moi Teaching and Referral Hospital (M.T.R.H) in Western Kenya. Progesterone was analyzed using Enzyme Linked Immuno-Sorbent Assay (ELISA) while flow cytometry method was used to analyze cytokines and lymphocytes. Categorical variables were analyzed using Pearson’s Chi-Square test. The changes and differences in the outcomes were assessed using repeated measures analysis of variance and Wilcoxon two-sample tests, respectively. The mean change in progesterone during the second, and the third trimesters were significant (P

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