ABSTRACT Objectives: to explore the anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models . Methods: The anxiolytic activity was examined by using the elevated plus maze (EPM) and open field test (OFT), hole board test and light and dark box exploration test. Twenty Swiss albino male mice were divided into five groups of four mice each. Group 1 received distilled water and served as negative control; group 2 received 100mg/kg of ECS; group 3 receiv...