Assessment of Testosterone , LDL and HDL Cholesterol among Females with Polycystic Ovary Syndrome

Abstract

Background: Polycystic ovary syndrome is a heterogeneous endocrine disorder

which affects 5–15% of the general population, depending on the ethnicity and the

applied classification system, Polycystic ovary syndrome (PCOS) is the most

common endocrine disorder in women of reproductive age It is characterized by

polycystic ovaries, oligo-amenorrhea, and hyperandrogenism.

Objective: The aim of this study is to assess testosterone, HDL-c and LDL-c in

patients with polycystic ovary syndrome (PCO).

Methods: This cross sectional study was conducted at Alsir Abu Hassan center for

fertility in Khartoum State, the study carried out on a total sample of 100 females

including 50 females with polycystic ovary syndrome patients as case and 50 healthy

females as control group. Serum testosterone levels was estimated using Enzyme

linked immune sorbent assay technique and serum HDL-c, LDL-c level was estimated

using spectrophotometer biosystem-310 . Data analyzed using SPSS software

program version20.

Results: This study showed that the levels of testosterone was significantly increased

with (p-value 0.000); while there was insignificant elevation in level of HDL-c, LDLc

with ( p-value HDL-c(0.412)and p-value LDL-c(0.957)) in polycystic ovary

syndrome patients compared to control group. When comparing polycystic ovary

syndrome patients according to menstrual regulation, infertility, duration , family

history, cosmetics and take of medication the study showed that there was significant

increase in testosterone across menstrual regularity ,duration, infertility , family

history, cosmetics and take of medication with (p-value 0.000) , and insignificant

deference in HDL-c LDL-c across menstrual regularity with (p-value 0.130)(p-value

0.207) infertility with (p-value 0.208) (p-value 0.254),, family history with (p-value

0.708)(p-value 0.254), cosmetics with (p-value 0.159)(p-value 0.320) and take of

medication with (p-value 0.571)

(p-value 0.574).

There was no correlation between testosterone levels with age, and body mass index

(R -0.177 P. value 0.218, R -0.554 P. value 0.708) and negative correlation with

duration (R -0.562 P. value 0.002) respectively. Also, there was no correlation

between HDL-c with duration, body mass index and with age (R 0.011 P. value

0.756** R -0.06 P. value 0.679**R -0.246 P. value 0.085) respectively and no

correlation between LDL-c with duration ,body mass index with (R 0.460 P. value

0.756** R 0.294 P. value 0.38) , and weak positive correlation with age with ( R

0.321 P. value 0.023).

Conclusion: From the results and finding of this study, it is concluded that:

The serum levels of testosterone are higher in PCOs female patients, and there are

observed change in HDL-c and LDL-c concentration PCOs female patients.

No correlations were found between BMI and age and serum levels of testosterone

HDL-c and LDL-c . No correlations were found between duration and serum levels

of HDL-c and LDL-c ,and negative correlation between duration and testosterone level.