Abstract Starches obtained from four Dioscorea species namely Dioscorea dumetorum (Bitter), Dioscorea oppositifolia (Chinese), Dioscorea alata (Water), and Dioscorea rotundata (White) have been evaluated as binding agents in chloroquine phosphate tablet formulations in comparison with official corn starch. The compressional properties of the formulations were analyzed using density measurements and the Heckel and Kawakita equations. The mechanical properties of the tablets were assessed usin...
Abstract This paper conducted an evaluation of repellent effect of neem seed oil formulated in a vanishing type cream base against Anopheles gambiae mosquito under laboratory conditions using human volunteers. The seed oil was extracted and then prepared in five different concentrations of 0, 2.5, 5.0, 7.5 and 10.0% w /w respectively in a vanishing cream base. A commercially available repellent Deet was used as control. The result shows that concentrations 2.5, 5.0, 7.5, and 10.0% w /w and D...
ABSTRACT Background: Substances extracted from lichens have previously been reported to possess antimicrobial activities against various groups of bacteria, fungi and viruses. Due to the high abundance of Parmelia perlata in the Eastern parts of Nigeria, we decided to explore whether it possesses antiviral activity against some common animal and human viruses. Methodology: The dried and powdered lichen was extracted with acetone, water and 4% (v/v) NaOH (to yield a crude polysaccharide fracti...
Abstract Objective; The quantitative effects of formulation and processing variables affecting the binding properties of Chinese yam starch ( Dioscorea oppositifolia) in chloroquine phosphate tablet formulations have been investigated in comparison with com starch using a 23 factorial experimental design. Methods: Chinese yam starch, representing the "low " level, and com starch, representing the "high" level were used as binders at concentrations of 2. 5 % w /w and 10 % w /w in chloroquine ...
ABSTRACT Objective: Lubricants are additives which reduce friction and so essential components of drug formulation. This piece of work was initiated to evaluate coconut oil as a co-processed lubricant in the formulation and compression of paracetamol tablets in comparison with magnesium stearatetalc as standard lubricant. Methods: Various concentrations 0.5, 1.5, 2.0 and 2.5% w /w lubricant mixtures of magnesium stearate-talc (MT), coconut magnesium stearate-talc (CMT), magnesium st...
The purpose of this work is to determine the biological activity and spectral analysis of Gas chromatography/mass Spectroscopy (GC-MS) profile of crude extract of S monbin,S.mombin L. (Anacardiacaea) is a plant that grows in almost every part of the world. It is fruitferious decidous plant of about 20m high that grows in the rain forest of Africa. Smombin parts were harvested early in the morning into a polythene bag. S.mombin plant (1kg) each of the different plant parts was extracted with 3...
The objective of this is to determine the qualitative and quantitative screening of phytochemicalanalysis of Spondias mombin (Linn) extracts (root, leaf, and stem bark) using different extraction solvent. The root, leaf, and stem bark of Spondias mombin plant were harvested early in the morning into a polythene bag at Oja Oba market, IkareAkoko, Ondo State, a tropical rainforest of Nigeria with latitude (7.21692 North) and longitude (5.21561 East). The Spondias mombin. Powdered plant material...