Pharmaceutics Research Papers/Topics

Flow characteristics and dispersion during drug delivery in a permeable microvessel

Abstract: Understanding how fluid flow and how solutes disperse in human bodies is crucial in Biomedical Engineering. The study of blood rheology is critical as it may help in detecting, designing a treatment for some blood related diseases and understanding them better. The aims of the present thesis is to study the effect of rheological parameters on blood flow and solute dispersion in a microvessel. Firstly the impact of stress jump condition and heterogeneous reaction on velocity, temper...

Investigating the Effect of Implementing Effective Management Control System: The Case Study of the Pharmaceutical Industry in Lesotho

Abstract: The main focus of this research study is the study of the effect of an effective management control system (MCS), the case study of Lesotho pharmaceutical companies. The primary objectives of the research study were to establish ways of implementing successful MCS in Lesotho's pharmaceutical companies, exceptionally efficient control of human resources, and to evaluate the effectiveness of the execution of MCS, looking at the pharmaceutical industries in Lesotho. For this purpose, ...

Novel Drug Delivery Systems Containing Artesunate and Amodiaquine

ABSTRACT Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered through the oral route. Rectal administration, which formed the basis of this work, is an alternative route of administration which overcomes the limi...

Evaluation of Phyto-Chemical and Medicinal Properties of Cannabis Sativa Linn. (Family Moraceae).

Abstract This work studied the various delivery systems (oral and parental formulations) of crude Cannabis. The stability, pharmacological and toxicological profiles of Cannabis resin in the formulations was also studied. Dried powdered leaves of Cannabis sativa L. were extracted with chloroform, the extract was concentrated to obtain an oil-based tar (resin) and its phytochemical composition determined. The Cannabis crude resin was formulated as syrup, capsule and suppository dosage forms. ...

Solid Dispersions Based on Peg 4000, Soluplus and their Hybrids for Enhanced Delivery of Glimepiride

ABSTRACT The present study investigates the possibility of enhancing the solubility, and hence the bioavailability of poorly water soluble glimepiride via formation of polyethylene glycolpolyvinyl caprolactam - polyvinyl acetate grafted copolymer (Soluplus®) and PEG 4000 based solid dispersions by solvent evaporation technique.Different batches of glimepiride solid dispersions (SD) were prepared using solvent evaporation method with Soluplus® and PEG 4000 as polymer matrix at different rat...

Protective Role of Aqueous Leaf Extract of Vernonia Amygdalina Del. (Asteraceae) And Ocimum Gratissimum Linn (Lamiaceae) in Cyclophosphamide Induced Urotoxicity and Myelosuppression

ABSTRACT Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced urotoxicity and myelosupression were evaluated using biochemical and histopathological approaches. Sodium -2-macarptoethane sulfonate (MESNA) was used as a p...

Antidiabetic Potentials of Lipospheres Encapsulating Anogeissus Leiocarpus Dc Guill & Perr Root Bark Methanol Extract

ABSTRACT The study was aimed at evaluating the antidiabetic potentials of Anogeissius leiocarpus DC Guill and Perr root bark methanol, ethanol and ethanol plus trona extract; and preparing, characterizing and evaluating lipospheres as drug delivery system loaded with A.leiocarpus root bark methanol extract. 400 mg/kg of methanol,ethanol and ethanol plus trona extracts of the A.leiocarpus root bark extracts were used in preliminary evaluation of antidiabetic effect of this plant root bark extr...

Evaluation of N- Hydroxymethyl Chlorphensin Carbamate and Ethionamide as Potential Prodrugs

ABSTRACT Chlorphensin carbamate is a centrally acting muscle relaxant, insoluble in water, readily absorbed from the gastro-inteatinal tract, when administered orally and highly metabolished. The mechanism of action is by depressing spinal polysynaptic reflexes. Neuronal conduction, neuromuscular transmission and muscle excitability are not depressed except after nearly lethal doses. This action led to its characterisation as inter-neuronal blocking agent and therefore used to relief symptoma...

Characterisation and Application of Grewia Gum in Tabletting

CONTENTS Page Title page ... . . . .-. I. Certification ..- ... . . . ... Dedication ... ... ..I ... Ack nowledgemen t ... -.. . . Abstract ... . ... I.. Contents ... -.. ... ..* CHAPTER 1 INTRODUCTION . . . . 0 0 1.1 Plant Gums -.. .-. ... 1.2 Sources of Plant Gums . . . ... 1- 3 Classification of Plant Gums *.- 1.4 Extraction and purification of Plant Gums 1.5 Cmposition and Structure of Plant Gums 1.6 Analysis of Plant ems .. . ..- 1.6.1 Qualitative Analysis ... .-. 1.7 Physic-chemical Pro...

Sustained Release Solid Lipid Nanoparticles Formulation of Lumefantrine and Ciprofloxacin

Title Page --- --- --- --- --- --- --- --- --- --- i Certification --- --- --- --- --- --- --- --- --- --- ii Dedication --- --- --- --- --- --- --- --- --- --- --- iii Acknowledgment --- --- --- --- --- --- --- --- --- --- iv Table of contents --- --- --- --- --- --- --- --- --- --- vi Abstract --- --- --- --- --- --- --- --- --- --- --- xii List of tables--- --- --- --- --- --- --- --- --- --- xvii List of figures--- --- --- --- --- --- --- --- --- --- xviii CHAPTER ONE: INTRODUCTION --- --...

Solid Dispersions Based on Peg 4000, Soluplus and Their Hybrids for Enhanced Delivery of Glimepiride

ABSTRACT The present study investigates the possibility of enhancing the solubility, and hence the bioavailability of poorly water soluble glimepiride via formation of polyethylene glycolpolyvinyl caprolactam - polyvinyl acetate grafted copolymer (Soluplus®) and PEG 4000 based solid dispersions by solvent evaporation technique.Different batches of glimepiride solid dispersions (SD) were prepared using solvent evaporation method with Soluplus® and PEG 4000 as polymer matrix at different rati...

Phytochemical and Antimicrobial Properties of the Stem Bark of Detarium Microcarpum (Case Alpiniaceae)

TABLE OF CONTENTS TITLE PAGE ... ... ... ... ... ... ... CERTIFICATION ... ... ... ... ... ... & DEDICATION ... ... ... ... ... ... ACKNOWLEDGEMENT ... .... ... ... ... ABSTRACT ... .... ... ... ... ... ... TABLE OF CONTENTS ... ... ... ... ... CHAPTER ONE INTRODUCTION 1.1 Aims of study ... .+. ,.. ... 1.2 Botanic Profile and Functional Properties of Deltrrrtin~ Micr-octrrprrm 1.3 Microorganisnl arid Diseases.. . ... ... ... ... . ,. 1.4 Phytochemicals ... ... ... ... ... ... ... ... 1.5 Anti...

Bioactivity-Guided Studies on the Crude Extract and fractions of Hibiscus Asper Hook F. (Malvaceae) Leaf

ABSTRACT The antibacterial and anti-inflammatory activities of the leaf extract of Hibiscus asper Hook F. (Malvaceae) were investigated. Solvent extraction of the leaves yielded the crude methanol extract (CME), while solvent-guided fractionation of CME yielded a n-hexane fraction (HF), chloroform fraction (CF), ethyl acetate fraction (EF), acetone fraction (AF), butanol fraction (BF), methanol fraction (MF) and water fraction (WF). TheCME and the solvent fractions were subjected to phytochem...

Predicting Intestinal Permeation of Drugs Through Neural Network Analysis Based on Five Molecular Descriptors

ABSTRACT The oral route is generally preferred for drug administration because of its ease and good patient compliance. In the search for new drugs for oral administration a major problem encountered is obtaining drug structures which, as well as being potent in viiro, possess favourable pharmacokinetic profiles which enable them to pass easily through the relevant body membranes, especially the gastrointestinal epithelia to effect their action. However, many of the compounds derived from com...

Assessment Of The Pharmaceutical Manufacturing Industry In Kenya To Forecast Local Production Sufficiency

ABSTRACT The World Health Organization’s global strategy on public health aims to support Member States to improve access to essential medicines. The desire of Kenya Government to implement this is expressed by formulation of Kenya National Pharmaceutical Policy (2010) which encourages local production of essential medicines for self-sufficiency. The pharmaceutical manufacturing industry in Kenya is engaged in production of various types of dosage forms but its capacity and capability to p...


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