Chemistry Research Papers/Topics

Kinetic And Equilibrium Studies Of The Reaction Of 5,5'-Dithiobis(2-Nitrobenzoate) With Haemoglobins Of Dog And Donkey

ABSTRACT The CysF9[93]β sulphydryl group is an indicator for tertiary and quaternary structure change in haemoglobin. Allosteric effectors such as proton and inositol hexakisphosphate (inositol-P6) influence its reactivity. This work was undertaken to study the effects of inositol-P6 and pH on the kinetics and equilibrium of the reaction of CysF9[93]β of dog (Canis familiaris) and donkey (Equus asinus) haemoglobins with 5,5'-dithiobis(2-nitrobenzoate) (DTNB). The number of sulphydryl groups...

The Synthesis Of Some Natural Products Of Medicinal Value Using Organometallic Complexes

ABSTRACT The challenge of accomplishing C-C bond formation while protecting sensitive functional groups and overcoming problems of stereo-control has led to the use of transition-metal organometallic compounds in organic compounds synthesis. Nucleophilic additions to cationic dienyliron carbonyl complexes provide a convenient means of C-C bond formation. It is highly regioselective and stereospecific making it useful for the synthesis of natural products and compounds with biological activiti...

ME EFFECT OF LEACHATE FROM SOLID WASTE DISPOSAL SITES ON THE CAPE COAST MUNICIPAL ENVIRONMENT

ABSTRACT As a developing countJy, Ghana is faced with the problem of management of her solid waste. Disposal ofsolid waste in open dumps and swampy areas in a bid to reclaim the land is the most common method used. This research was carried out at the Cape Coast Municipality to investigate the effect of disposed solid waste on the environment. The methodologies are purposive sampling for the solid waste evaluation, titrimetric and spectrophotometric for the analysis of the leachate from the ...

SYNTHESIS OF THE COMPLEXES OF 4-CY ANOBENZALDEHYDECYCLOHEXYLACE TIC ACIDHYDRAZONE WITH M(II) SULPHATES AND ACETATES. (M= Ni, cu, Co, Zn)

Complexes of 4 - Cyanobenzaldehydecylohexyl acetic acid hydrazone ( 4-CBAH) with M(II) sulphates and acetates have been synthesized (M=Ni, Cu, Co and Zn). The complexes were characterized by elemental analyses, conductance, infrared and electronic spectral studies. The sulphate ions are in the outer coordination sphere, so also the acetate 10ns. The electronic spectral studies of the isolated complexes indicate an octahedral coordination for Ni 2 + and Co 2 + complexes while Cu 2 +...

SYNTHESIS OF A QUATERNARY AMMONIUM SALT FROM EPOXIDE AND FATTY AMINE AND EVALUATION OF ITS ANTIMICROBIAL PROPERTIES

Quaternary ammonium compound was synthesized from epoxy and fatty amine reaction. Fourier Transform Infrared(FTIR) spectrometric analysis of the starting materials, and the final product(N-benzyl-N,N-dioctyl-2-hydroxy-3 phenoxypropylammonium chloride) were conducted, and results showed a disappearance of sharp N-H peak of 2oamine, and appearance of broad O-H peak of alcohol in the spectrum of the final product. Mass spectrometric(MS)analysis of the final product was also conducted, and ...

ASSESSMENT OF THE LEVELS OF HEAVY METALS IN SEDIMENTS, WATER AND FISH FROM THE WEIJA DAM

ABSTRACT This study was conducted to assess the levels of heavy metal contaminations within the Weija dam area of the Weija Lake. Sediments, water and fish samples were taken from ten different sites within the Weija dam in March, 2014 (dry season) and August, 2014 (wet season). The sediment, water and fish samples were analysed for Hg, Se, Fe, Cd, Mn and Pb using Atomic Absorption spectroscopy (AAS). Mercury was determined using a cold vapour technique with the AAS equipped with hydride gene...

SYNTHESIS AND CHARACTERISATION OF NOVEL SEMICONDUCTING SMALL MOLECULES FOR APPLICATIONS IN ORGANIC SOLAR CELLS.

Abstract Five novel semiconducting organic small molecules have been synthesised, fully characterised, and their photovoltaic performance tested in fabricated organic solar cells. Three (molecules 5, 7 and 9) were acceptor-donor-acceptor (A-D-A) small molecules bearing an electron-rich (3,4- ethylenedioxythiophene) EDOT central core with different terminal groups. The additional two (molecules 20 and 21) were truxene derivatives which have been differentiated by the alkyl chain length on the ...

POST MARKETING SURVEILLANCE OF ACTIVE PHARMACEUTICAL INGREDIENTS (API) IN ANTIMALARIAL DRUGS USED IN MALAWI

ABSTRACT The use of poor quality antimalarials causes low bioavailability of the active pharmaceutical ingredients (APIs) to the drug targets resulting in treatment ineffectiveness or failure and parasite resistance over a short period of drug usage. Resistance has rendered the hitherto cheap and effective drugs like chloroquine and sulphadoxine/pyrimethamine ineffective, resulting in their replacement with the more expensive artemisinin-based combination therapy (ACT) for malaria treatment. ...

STUDIES OF VALEROHYDROXAMIC AND ' ISOVALEROHYDROXAMIC ACIDS AND OF THEIR COMPLEXES WITH SOME BIOLOGICALY IMPORTANT METAL IONS

Valerohydroxamic and Isovalerohydroxamic acids were synthesised and recrystallised from ethylacetate. They were characterised by melting point, pka and spectral (IR NMR) studies. Their melting points are 77.78°C and 76.77°C for valerohydroxamic acid and isovalerohydroxamic acid respectively and their pka values at 0.1mol dm-3 at 28°C are 9.50+0.01 and 9.51+0.01 for valerohydroxamic acid and isovalerohydroxamic acid respectively. The IR and NMR (1H and 13C) for both valerohydroxamic...

STUDIES OF ALUMINIUM COMPLEXES OF SOME MODEL BIOLOGICAL LIGANDS

Complexes of Aluminium with some model bioligands, were prepared and characterized by elemental analysis, melting point, conductivity, solubility and infra-red spectroscopic studies. The complexes are soluble in water and some organic solvents such as chloroform, ethanol and methanol. The melting point ranges from 258°C - 282°C for complexes with Al Cl3, and 8Ql C - 95 C, for complexes with AlNH4(S04) 2 .12H2 0. Conductivity studies reveals that the prepared· complexes are non-electr...

Monitoring of Elemental Composition of Honey from Selected Regions of Ghana Using Instrumental Neutron Activation Analysis and Atomic Absorption Spectroscopy

ABSTRACT Honey is a sweet, thick and viscid fluid collected from beehives and usually found in cells of the honey comb. It is produced from nectar collected from various flowers by honeybees and processed. Among the important uses, pure and undiluted honey serves as natural sweetener and contains a broad variety of vitamins for human consumption. Due to its global demand, monitoring of the quality of honey is of great significance. In this study, honey samples were collected systematically fr...

PIIYTOCHEMICAL AND BIOLOGICAL STUDIES ON COMMIPHORA AFRICANA (BURSERACEAE) ROOT

The ethanolic extract (crude extract) was successively extracted with n hexane, chloroform, water, 103 aqueous methanol and n_hexane to give the corresponding fractions. The crude exfract, 103 "aqueous methanol, vvater soluble and n-hexane fractions of the root of .c_.africana, were screened for antimicrobial activity and chemical constituents. The n-hexane fraction was chromatographed on a column of silica gel to give a number of fairly pure components. The infrared spectra of the comp...

THE PHYSICO-MECHANICAL AND MORPHOLOGICAL PROPERTIES OF -CELLULOSE-FILLED POLYSTYRENE (PS) AND POLYVINYL ACETATE (PVAc) BLENDS

Studies of physico-mechanical and morphological properties of pure and -cellulose reinforced blends of polystyrene (PS) and poly (vinyl acetate) (PVAc) are reported in this work. The compression moulded articles of the blends of different compositions (10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20 and 90:10, PS/PVAc) were tested for mechanical performance, absorption behaviour, void activity and morphological arrangements. Comparison of mechanical properties such as tensile...

KINETIC STUDIES OF SELECTED CORROSION INHIBITORS OF ALUMINIUM AND MILD STEEL IN ACID MEDIUM

The corrosion inhibition of aluminium and mild steel in H2SO4 in the presence of Bromothymol blue, BTB, Dimethyl yellow, DMY, Methyl orange, MO, Titanium (IV) oxide, TO and Cassia Siamea Lam, CSL leaves extract at 303 – 313K was studied using “Absorbance difference” technique. The results showed that inhibition efficiency (%IE) increased with increase in inhibitor concentration (except for BTB, where beyond a “critical” concentration of 0.0007M, it reversed its function and bec...

SPECIATION OF INORGANIC ANTIMONY IN POLYETHYLENE TEREPHTHALATE (PET) BOTTLED WATER USING HYDRIDE GENERATION ATOMIC ABSORPTION SPECTROPHOTOMETRY

ABSTRACT Antimony (Sb) is a regulated drinking water contaminant that has been found to leach from polyethylene terephthalate (PET) plastic containers into the waters stored in them. The common inorganic species of antimony in water are Sb(III) and Sb(V), with the former being more toxic and the latter being more soluble. In order to assess the extent to which waters stored in PET bottles are contaminated with inorganic Sb and to further examine the effect of typical storage conditions on mig...


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