Abstract Background: Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic Plasmodium falciparum transmission regions, such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dl] is the primary form of severe disease. Ubiquitination is essential for regulating intracellular processes involved in innate and adaptive immunity. Although dysregulation in ubiquitin molecular processes is central to the pathogenesis of multiple hu...
Abstract Lake Victoria, the second-largest freshwater lake in the world, provides an important source of food and income, particularly fish for both domestic consumption and for export market. In recent years, Lake Victoria has suffered massive pollution from both industrial and wastewater discharge. Microplastic biomes, pharmaceutical residues, drugs of abuse, heavy metals, agrochemicals, and personal care products are ubiquitous in the aquatic ecosystem of Winam Gulf. These pollutants are ...
Abstract Background Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. P. falciparum exerts strong selection pressure on sickle cell trait (SCT), alpha thalassemia (-α3.7/αα), glucose-6-phosphate dehydrogenase (G6PD), and merozoite surface protein 2 (MSP-2) variants (FC27, 3D7) that confer reduced malarial disease severity. The cu...
Plants have been known to be used in the treatment and management of diseases, and this is due to the presence of phytochemicals. Thus, the screening of plants qualitatively, has got the interest of researchers. Moringa Oleifera is a fast growing deciduous tree with its different plant parts commonly used in herbal medicine, also with good socio-economic and industrial values. In this study qualitative photochemical screening was carried on Moringa oleifera leaves extract to test for alkal...
Abstract: Antibiotic resistance has been a growing worldwide public health issue. The World Health Organization (WHO) has stated that the search for new antibiotics is slow, while antibiotic resistance is growing. WHO has also declared that antibiotic resistance is one of the top 10 global public health threats facing humanity in the 21st century. Therefore, this review discusses the potential of metal-based drugs as antibacterial agents from the period of the early 2000s to date. The review...
Abstract: Human African Trypanosomiasis (HAT) is present in 36 sub-Saharan African countries. The disease is easier to treat in early stage than late stage when treatment with melarsoprol is responsible for significant fatality. Therefore there is need to develop a diagnostic test for early detection before progression of the disease into the late stage. Currently available tests have poor sensitivity. Thus highly sensitive methods are needed for the detection of the parasite in human blood....
Abstract: Ethnobotanical analyses highlight therapeutic and chemotypic variations of geographically and ecologically diverse Murraya koenigii (Spreng) samples. However, the genetic correlation of this observation remains obscure. The present study aimed at studying the intraspecific genetic variation of Murraya koenigii and the possible effect on the bioactivity of volatiles of plant samples collected from four different geographical locations of Kenya. Genomic DNA isolated from various plan...