Formulation factors affecting the binding properties of Chinese yam ( Dioscorea oppositifolia) and corn starches

Abstract

Objective; The quantitative effects of formulation and processing variables affecting the binding properties of Chinese yam starch ( Dioscorea oppositifolia) in chloroquine phosphate tablet formulations have been investigated in comparison with com starch using a 23 factorial experimental design. Methods: Chinese yam starch, representing the "low " level, and com starch, representing the "high" level were used as binders at concentrations of 2. 5 % w /w and 10 % w /w in chloroquine phosphate tablet formulations. The mechanical properties of the tablets, measured by the tensile strength ( T ) and brittle fracture index ( BFI) as well as the release properties measured by the disintegration time (D T ) and dissolution time ( t g0- time for 80 % drug release) , were used as assessment parameters.