Human Pluripotents Stem Cells Application And Drugs Recovery And Toxicology

INTRODUCTION

Human pluripotent stem cells (hPSCs) are a type of stem cell with the remarkable ability to self-renew and dierentiate into various cell types of the human body (NIH, 2020). There are two main types of hPSCs: embryonic stem cells (ESCs) derived from the inner cell mass of blastocysts, and induced pluripotent stem cells (iPSCs) generated from adult cells through reprogramming (Takahashi et al., 2007). These cells hold great promise for biomedical research and have revolutionized the eld of regenerative medicine. The development of new drugs is essential for addressing unmet medical needs and improving human health. Drug discovery involves a complex and expensive process of identifying potential drug candidates, assessing their ecacy, and evaluating their safety proles (Adams & Brantner, 2006). Ensuring the safety of drugs is equally crucial to protect public health, as unforeseen toxicological effects can have severe consequences. Toxicology plays a vital role in assessing the potential risks associated with exposure to various chemicals, including pharmaceutical compounds (NRC, 2007). Human pluripotent stem cells oer unprecedented opportunities to advance drug discovery and toxicology research. These cells can be dierentiated into specic cell types and tissues, providing a platform to model human diseases and study drug responses in a controlled environment. By recapitulating disease processes, hPSC-based models enable the identication of new therapeutic targets and the development of personalized medicine approaches (Sinha et al., 2018). Moreover, hPSCs have the potential to transform toxicological testing by oering more accurate and predictive models to assess the safety of chemicals and drugs (Takahashi et al., 2007).