Abstract
Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury. KV was administered at a dose of 100 or 200 mg/kg to male Wistar rats 1 h before a 30 min BCCAO/4 h reperfusion (I/R). This was followed by neurobehavioral assessment
and biochemical evaluations of cation levels, oxidative acetylcholinesterase (AChE) activity in the brain of animals. KV significantly restored altered cortical and striatal Ca2+, Na+, K+ and Mg2+ levels, ameliorated redox imbalance, lactic acidosis and modified AChE activity caused by I/R injury. The favourable neurobehavioural effects of KV correlated with biochemical outcomes. The pharmacological potential
of KV in the treatment and management of ischemic stroke and allied pathological conditions via multiple targets (neurotransmitter metabolism, bioenergetic failure and ionic homeostasis) is highlighted by the study.
TABLE OF CONTENT
1. ABSTRACT
2. INTRODUCTION
3. MATERIALS AND METHODS
4. RESULTS
5. DISCUSSION
6. CONCLUSION
7. ETHICAL APPROVAL
8. DISCLOSURE STATEMENT
9. REFERENCES
Olowookere, B. & Akinmoladun, A (2019). Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir. Afribary. Retrieved from https://track.afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro
Olowookere, Boyede, and Afolabi Akinmoladun "Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir" Afribary. Afribary, 27 Jun. 2019, https://track.afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro. Accessed 23 Nov. 2024.
Olowookere, Boyede, and Afolabi Akinmoladun . "Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir". Afribary, Afribary, 27 Jun. 2019. Web. 23 Nov. 2024. < https://track.afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro >.
Olowookere, Boyede and Akinmoladun, Afolabi . "Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir" Afribary (2019). Accessed November 23, 2024. https://track.afribary.com/works/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviro