SYNTHESIS AND CHARACTERIZATION OF PYRIDYL BASED SCHIFF

Overview
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Metal complexes are scientifically known to be active and effective as antibacterial, antivirus and some antifungal etc. This project work is targeted at preparing complex from transition metals say; cobalt, cupper, zinc and nickel and organic ligands synthesised from pyridyl based schiff bases, one from 2-aminopyridine and benzaldehyde and second from 2-aminopyridine and 2,4-dihydroxylbenzaldehyde. The analysis and completion is based on thin-layer chromatography, column-chromatography and IR-spectral analysis.

TABLE OF CONTENT

Dedication………………………………………………… i

Content………………………………………………………ii

Acknowledgement…………………………………………….iii

Abstract…………………………………………………………iv

List of figures……………………………………………………v

List of tables……………………………………………………..vi

List of equations…………………………………………………vii

List of tables………………………………………………….. viii

CHAPTER ONE

LITERATURE REVIEW

Introduction

The chemistry of transition elements

Objectives of study

Complexes of transition elements

why metal complexes are coluored

the nature of chemical bonding in transition metal complexes

Effect of the complex constituents

Effect of ligands

Effect of metal ion

The coordination chemistry of metal used (Nickel)

The chemistry of Schiff Base (Imine)

The Biological importance and activity of Schiff Base

Ligand studied

Pyridyl based Schiff Base

1.10. Apllications and activities of Schiff base complexes

CHAPTER TWO

1.MATERIALS AND EQUIPMENT

2.1. REAGENTS

2.1.1. Ethanol

2.1.2. Benz aldehyde

2.1.3. 2, 4-dihydroxylbenzaldehyde

2.1.4. Methanol

2.1.5. Glacial acetic acid

2.1.6. Diethyl ether

2.1.7. n-hexane

2.1.8. 2-aminopyridine

2.1.9. Distilled Water

2.10. Dichloromethan

2.11. Nickel metal salt

2.12. Terpene oil

2.13. Silica gel

2.2.EQUIPMENT

2.2.1. Reflux setup

2.2.2. Distillation setup

2.2.3. TLC plate and its materials

2.2.4. UV machine

2.2.5. Trituration setup

2.2.6. Column chromatography setup

2.2.7 Chemical Balance

2.3. EXPERIMENTAL TECHNIQUES AND PROCEDURES

2.3.1. General cleanupof glass wares and other apparatus

2.3.2. Distillation of Benz aldehyde

2.3.3. Refluxing to prepare our Schiff base in without catalyst

2.3.4. Refluxing to prepare our Schiff base with catalyst

2.3.5. Concentration using rotary evaporator

2.3.6. Running of TLC check

2.3.7. Trituration of Schiff base produce from 2, 4-dihydroxyl benzaldehyde with diethylether and methanol in different setup

2.3.8. Purification with column chromatography

2.3.9. Refluxing of the Schiff base with the metal salt (copper nitrate)

CHAPTER THREE

3.1 RESULTS

3.1.1. Melting point results

3.1.2. FTIR results and analysis

CHAPTER FOUR

4.1 Discussion of result

4.2 Conclusion

4.3. References.

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SYNTHESIS AND CHARACTERIZATION OF PYRIDYL BASED SCHIFF

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