Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortality rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each for aspirin and indomethacin models respectively. For each model, twenty five adult rats divided into five groups of four rats each were used for ulcer s...
Adverse drug reactions (ADR) triggered by a drug or its metabolites is an essential aspect of the post-clinical phase in the drug discovery pipeline. The pathophysiology of ADRs has been described in two ways; expected and idiosyncratic. In the current study, we deployed valid computational tools to predict the ability of eight green tea polyphenols to favourably interact with HLA-B*57:01 and mediate idiosyncratic ADRs. First, we deployed molecular docking to understand the free energy profil...
ABSTACT The pharmacological effects of the metanolic root extract of the plant Alafia barteri Oliv. used commonly in West and Central Africa, from Guinea Bissau east to Cameroon and south to Congo, including Nigeria for the treatment of various diseases (including malaria, arthritis, eye infection an inflammation) was evaluated. The analgesic effect of the metanolic root extract of Alafia barteri (100, 200 and 400mg/kg) was evaluated in mice using Acetic acid induced writhing, Formalin induc...
Rauwolfia vomitoria is a natural medicinal herb which has been used over the years for the treatment of hypertension and mental disorders. This is to investigate the inhibitory effect of RAUWOLFIA VOMITORIA aqueous root extract on invitro isolated rabbit intestine precontracted with Acetylcholine. The effect of the root extract was compared with adrenaline.seven healthy adult rabbit bred in the animal house of college of basic medical science delta state university,abrake were alowed to aclim...
ABSTRACT Malaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and observe effect of combined treatment of chloroquine and artesunate on white blood cell count of P. berghei infected albino mice. A total of 15 ...
Cancer being one of the leading causes of death worldwide Many active secretions produced by animals have been employed in the development of new drugs to treat cancer. There is urgent need to search for new drugs from natural products. In recent years, remarkable progress has been made for the treatment of cancer. The major drawback of the current methods of cancer treatment is the therapies after initial treatments. It has led to the increased use of anticancer drug developed from natural s...
ABSTRACT The Sympathetic nervous systems (SNS) is an efferent division of the Autonomic nervous system (ANS) with neurons which anatomically originates in the central nervous system (CNS). It has a short preganglionic neuron which comes from the thoracic and lumbar regions (T1 to L2) (also termed, thoracolumbar outflow) of the spinal cord. The axons of the postganglionic neuron extend from these ganglia to the tissues that they innervate and regulate. In most cases, the preganglion...
ABSTRACTNitric oxide is produced in high amount from the break down of arginine by a group of enzyme called nitric oxide synthase. Nitric oxide is an intercellular messenger that has been recognized as one of the versatile player in the immune system. Cells of the innate immune system such as macrophages, neutrophil and natural killer use patterns recognition receptors to recognize the molecular patters associated with pathogens. The specific role nitric oxide plays depend on the place o...
'Drug abuse' is no longer a current medical diagnosis in either of the most used diagnostic tools in the world, the American Psychiatric Association's Diagnosticand Statistical Manual of Mental Disorders (DSM), and the World Health Organization's International Statistical Classification of Diseases and ICRIS Medical organization Related Health Problems (ICD) Substance abuse has been adopted by the DSM as a blanket term to include drug abuse and other things, while the ICD uses the term Harmf...
OVERVIEW The role of ACE inhibitors (Lisinopril) in reproductive function remains controversial. Some benefits seem to be derivable even in non-hypertensive males with low doses. This study was done using rat model to establish this fact. Male rats were divided into different groups to receive different doses of lisinopril. A control group received no drugs. The mean arterial pressure fell the most with 5mg of lisinopril. The greatest increase in sperm count and motility was recorded for this...