Aim: The study evaluated the chemical contents and antioxidant potential of aqueous extract of Irishpotato tubers traditionally used for ulcer treatment in Nigeria.Methods: Freshly harvested Irish potato tubers were purchased from Aba grocery market, AbiaState. They were thoroughly washed in running water, peeled, sliced and dried in an oven at 60ºC toa constant weight. The dried potatoes were milled into fine powder (flour) and extracted using wateras the solvent. The proximate, mineral, ph...
Background: Bigi soft drinks are carbonated drinks produced by Rite Foods Limited. Thecompany is an indigenous company in Nigeria. Before 2016, Coca-cola bottling company and 7upbottling company products were the dominant soft drinks in Nigeria. Rite Foods Limited introducedcarbonated soft drinks into the Nigerian market in 2016 and have favourably competed with theexisting products. As at today, Bigi soft drinks are the dominant soft drinks in Nigeria because oftheir palatable taste, large v...
Background: Hypertension has become a common sickness in Nigeria especially amongpopulation above 50 years of age. It constitutes a major riskfactor for several cardiovasculardiseases suchas atherosclerosis, heart failure, renal insufficiency, coronary artery disease andstroke.Aim: This study was aimed at evaluating the antihypertensive potential of coconut water in Wistarrats.Materials and Methods: Thirty Wistar rats were divided into three groups of ten each. Rats ingroups 1 and 2 received ...
The use of Carica papaya leaves in folklore medicine for its antimalarial andantidiabetic activities without reference to its adverse effect is on theincrease globally. This study therefore sought to investigate the antifertilityeffect of C. papaya leaves in male Wistar rats. Fresh and healthy leaves of C.papaya disease were harvested from the Institute of Agricultural Researchand Training, Moor Plantation, Ibadan. They were dried and extracted usingsoxhlet apparatus and ethanol as the solven...
Background: The growing number of diabetes coupled with the harsh side effects of somesynthetic drugs has led to the increasing search for alternatives which are relatively cheap withminimal side effects.Aim: This study sought to investigate the antidiabetic potential of alkaloid extracts from Vitexdoniana and Ficus thonningii leaves on alloxan-induced diabetic rats.Methods: Fresh leaves of V. doniana and F. thonningii were obtained from a local market Nkwaguin Abakaliki local government area...
The growing number of diabetes coupled with the harsh side effects of some synthetic drugs has led to the increasing search for alternativeswhich are relatively cheap with minimal side effects. This study sought to investigate the antidiabetic effect of ethanolic extract of Carica papaya leavesin alloxan-induced diabetic rats. Thirty adult male albino rats were induced intraperitoneally with alloxan. The rats were grouped into six groups offive animals per group: Group A was not induced with ...
Background: The search for newer sources of antibiotics is a global challenge pre-occupyingresearch institutions, pharmaceutical companies and academia, since many infectious agents arebecoming resistant to synthetic drugs.Aim: This present study sought to investigate the antibacterial potential of ethanolic and aqueousextracts of Carica papaya leaves.Materials and Methods: Fresh and healthy leaves of C. papaya were harvested, air dried andmilled into powder. The powder was extracted using et...
There is a general believe that bitter kola isan aphrodisiac agent, thus men consume it to enhancetheir libido. This study is aimed at assessing theeffect of bitter kola on male sex hormones. Twentyfour adult male Wistar rats were randomly dividedinto four groups of six each after seven daysacclimatization period. Animals in group 1 wereadministered normal saline solution while those ingroups 2, 3 and 4 were administered 100, 200 and400 mg/kg body weight of bitter kola extractsrespectively fo...
This study is aimed at evaluating theameliorative effect of Parkia biglobosa againstegg-yolk induced hypertension. In order toachieve this, 30 Wistar rats were divided intothree groups of 10 each. Rats in group Areceived normal feed diet and they served as thecontrol group while those in groups B and Creceived a special prepared egg feed diet (24 eggyolk mixed with 1 kg of normal rat diet).Animals in group C were administered400mg/kg body weight of P. biglobosa extractsimultaneously with the ...
The presence study aimed to investigate the phytochemical and heavy metals level in selected vegetables grown in Kalambaina area ,the phytochemical were determined using analytical methods and the heavy metals (Cd, Pb, Zn, Ni, Cr and Cu) concentration in vegetables and water were determined using atomic absorption spectroscopy (AAS). The study indicate the presence of flavanoid, alkaloids, steroids, volatile oil, saponin glycosides in all the vegetables. The concentration of copper was found ...
ABSRACT Chlorpyrifos [CPF; O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothionate] is a widely used organophosphate pesticide that is known to be toxic to the environment and to living beings. It affects several organs of the body especially the brain leading to impairment of normal functioning of the body. Diphenyl diselenide (DPDS), an organsoselenium compound is the simplest of the synthetic diaryldiselenides. Studies have shown that DPDS exhibits anti-inflammatory and antioxidant e...
INTRODUCTION Oxygen is an indispensable element for life. Oxidative property of oxygen plays a vital role in various biological phenomena; being essential for life, oxygen can also aggravate the damage within the cell by oxidative events. Oxygen is used by the cell to generate energy and free radicals are formed as a consequence of ATP (adenosine triphosphate) production by the mitochondria. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the by-products resulting from t...
ABSTRACT The neuromuscular junction (NMJ) is a unique, specialized chemical synapse that plays a crucial role in transmitting and amplifying information from spinal motor neurons to skeletal muscles. NMJ complexity ensures closely intertwined interactions between numerous synaptic vesicles, signaling molecules, ion channels, motor neurons, glia, and muscle fibers, making it difficult to dissect the underlying mechanisms and factors affecting neuro-degeneration and muscle loss. Muscle fiber...
Parkinson’s disease is a degenerative neurological disease, which is characterized by the preferential death of dopaminergic neurons in the Substantia Nigra. Current drug treatments are aimed primarily for the treatment of symptoms to improve the quality of life. Therefore, there is a need to find out new therapeutic strategies that not only provide relief but also halt or reverse the neuronal damage hampering PD progression, thus this research therefore aimed at investigating the impact o...
ABSTRACT The place of adequate nutrition in the live of the young especially in the recently weaned cannot be overemphasized. The abrupt change in diet, leading to possible immune system weakness and disease conditions, is a focal point in the care of the young. This project examined serum globulin and bilirubin levels in weanling rats whose feed was supplemented with Emilia sonchifolia leaf extract.Present investigation were carried out on the effect of ethanolic extract of Emilia Sonchifo...