Adverse drug reactions (ADR) triggered by a drug or its metabolites is an essential aspect of the post-clinical phase in the drug discovery pipeline. The pathophysiology of ADRs has been described in two ways; expected and idiosyncratic. In the current study, we deployed valid computational tools to predict the ability of eight green tea polyphenols to favourably interact with HLA-B*57:01 and mediate idiosyncratic ADRs. First, we deployed molecular docking to understand the free energy profil...
EFFECTS OF COCONUT (Cocos nucifera) WATER ON REPRODUCTIVE FUNCTIONS IN DANAZOL (GnRH-Antagonist) TREATED MALE WISTAR RATS Oyovwi M.O., Kunle-Alabi., Akndele O., Duro-Ladipo M.A.,Raji Y . Laboratory for Reproductive Physiology and Developmental Programming, Department of Physiology, College of Medicine University of Ibadan ABSTRACT Coconut water has been reported to be implicated with many nutritional and medicinal application but its effect on reproductive function is yet to be eluci...
ABSTRACTBackgroundHand washing is the process of decontaminating the hands, a cheap and effective method of limiting the spread of nosocomial infections. Good hand hygiene involves cleansing hands in between patients or between examining an infected site and a clean body site on the same patient. Proper hand washing practice involves following the WHO accepted guidelines for hand washing. Hand washing is an effective and inexpensive way to prevent diarrhea and acute respiratory infections. Th...
In the study, health risk assessment on heavy metals ingestion was presented through the groundwater drinking pathway for residents in an oil and gas producing area of Rivers State, Nigeria. The level of the ground water pollutionwas examined, the quality of the borehole and the well water was assessedand the quality of the ground water pathway for the resident in the oil and gas producing area was determined and compared with the national and international standards for the drinking water. T...
Abstract The basic point in this paper is to emphasize drug withdrawal as a therapeutic process requires for many clinical treatments to be complete. The states of nature that are influenced with drugs can undergo conformational changes to heal a disease or rid and infection. these changes nay need to be returned to their normal states of nature before the infliction. therefore the drug withdrawal seeks a near perfect clinical administration where patients are well treated and body system cle...
ABSTRACT Imaging facilities within the Port Harcourt metropolis are ever on the increase, imaging practitioners are constantly trained and deployed into the work force. An issue constantly facing the imaging and radiology practice is the issue of work safety. Against this background, this study specifically aims at assessing safety measures employed in the design and construction of imaging centres in the Port Harcourt metropolis. A case study design was employed to investigate into 3 imagin...
There is increased problem in Nigeria today as to moral laxity, promiscuity, unwanted pregnancy, abortion, Sexually Transmitted Infection (STI), forced marriage, school dropout etc. among youths. The increase in these problems according to Orieh (1981, as cited in Nakpoda, 2012) has been attributed to ignorance of youth towards sexual health, confusion and frustration resulting from lack of awareness from both the home and the school on the need for sex education in the educational setting. ...
The purpose of this work is to determine the biological activity and spectral analysis of Gas chromatography/mass Spectroscopy (GC-MS) profile of crude extract of S monbin,S.mombin L. (Anacardiacaea) is a plant that grows in almost every part of the world. It is fruitferious decidous plant of about 20m high that grows in the rain forest of Africa. Smombin parts were harvested early in the morning into a polythene bag. S.mombin plant (1kg) each of the different plant parts was extracted with 3...
This research project studied the effect of ethanolic leaf extract of Dialium guineense Willd (Fabaceae) on oral glucose tolerance in mice and alloxan-induced diabetic female rats. The ethanolic leaf extract was prepared by marcerating 500g of the dried, milled leaves of D. guineense in 3L of 96% ethanol in a suitable sized plastic bucket/bowl (with cover) for five days with intermittent stirring (at least once a day) using a glass rod. Then the extract was filtered using Whatsman No.1 fil...
Diabetes mellitus has emerged as a global health care problem with significant economic burden. In order to prevent target organ damage and other complications that may arise from diabetes mellitus, good glycaemic control is imperative. Numerous factors have been found to influence glycaemic control among type 2 diabetic patients. Among these factors are social support and diabetic self-care practices. Studies have shown that increased support from family is positively related to patient’...
Abstract According to the available literature, West African mothers usually breastfeed for 12 months. Many urban poor and rural women breastfeed for up to 18 to 24 months. These reports indicate that there is early supplementation with solid foods or early weaning. Although the majority of women start weaning their infants at the age of three to four months, a few begin within the first two months of life. The first solid food and the most popular weaning food is a thin cereal gruel that is ...
Abstract: Although avertable and treatable, pneumonia is still one of the top five causes of mortality in the developing world especially in Southern Africa. One major challenge being faced globally today in the field of public health is the pneumococcal resistance to antibiotics both in infants and adults. The purpose of this review was to compare rates and causes of treatment failure in South Africa, Zambia, Malawi, and Mozambique. Articles used for this review were searched for in electro...
ABSTRACT Aim: To evaluate the anti-diabetic effect of aqueous extract of Saccharum officinarum (stem bark) in the genomic DNA of diabetic Wistar rats. Methodology: 15 Streptozotocin-induced diabetic male rats and five non diabetic rats were randomly and evenly distributed into four groups, and were subsequently exposed to the following treatments for 14 days: Group I (Control): Distilled water (1ml/kg B.W); Group II: Normal saline (1ml/kg B.W); Group III: treated Diabetic rats (Metformin) (50...
Mosquitoes are vectors of parasites causing diseases and are distributed in various ecological niches. This research work was set to determine the distribution and relative abundance of mosquito larvae in Guyuk Local Government Area of Adamawa State within the months of August 2014 and January 2015. Banjiram, Guyuk, Bobini and Chikila districts were surveyed using standard entomological procedures. Dipping Method was used in collecting larval samples from the field and reared to adult in inse...
The objective of this is to determine the qualitative and quantitative screening of phytochemicalanalysis of Spondias mombin (Linn) extracts (root, leaf, and stem bark) using different extraction solvent. The root, leaf, and stem bark of Spondias mombin plant were harvested early in the morning into a polythene bag at Oja Oba market, IkareAkoko, Ondo State, a tropical rainforest of Nigeria with latitude (7.21692 North) and longitude (5.21561 East). The Spondias mombin. Powdered plant material...