Medical & Health Sciences

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Medical & Health Sciences Research Papers/Topics

Therapeutic uses of stingless bee honey by traditional medicine practitioners in Baringo County, Kenya

Abstract African traditional medicine knowledge, skills and practices have often been passed verbally from the older generation to the younger generation. However, the current traditional medicine practitioners (TMPs) are rapidly aging, while the younger generation is not taking up the practice. Therefore, this study aimed at documenting the therapeutic uses of stingless bee honey among TMPs in Baringo County. Briefly, 91 TMPs were conveniently sampled and interviewed using an interviewer-ad...

Mutational signatures for breast cancer diagnosis using artificial intelligence

Abstract Background Breast cancer is the most common female cancer worldwide. Its diagnosis and prognosis remain scanty, imprecise, and poorly documented. Previous studies have indicated that some genetic mutational signatures are suspected to lead to progression of various breast cancer scenarios. There is paucity of data on the role of AI tools in delineating breast cancer mutational signatures. This study sought to investigate the relationship between breast cancer genetic mutational prof...

Screening and Prioritization of Pesticide Application for Potential Human Health and Environmental Risks in Largescale Farms in Western Kenya

Abstract Pesticide application in agricultural and residential areas is a worldwide practice. However, human pesticide poisoning and environmental pollution through pesticide residues remain a challenge in the developing world. The present study investigated the intensity of pesticide application in large-scale farms in Trans-Nzoia County to screen and prioritize the pesticides for potential human health and environmental risks. A cross-sectional survey involving 348 farmers was conducted in...

Maternal Mental Health Needs When the Unexpected Happens: A cross-sectional study among mothers with preterm infants in Western Kenya

Abstract Background: Mothers of preterm infants are usually unprepared for the baby’s birth earlier than expected, making them face emotional problems. Preterm births have increased lately with World Health Organization reporting an estimated prevalence of up to 5–18% and Kenya reporting an 18.3% prevalence. Mothers of preterm infants need special support to help them cope with this stressful event. The study determined the mental health needs of mothers with preterm infants in the neona...

Knowledge and Attitude of Health Managers Towards the Annual Health Sector Planning and Budgeting Process in Bungoma County, Kenya

Abstract The focus of health planning and budgeting is to identify priorities that, in turn, guide budgetary allocations aimed at improving health outcomes. The shift towards decentralization has necessitated reforms in the planning and budgeting processes. These reforms encompass the enactment of legislation, the formulation of process guidelines, and the utilization of program-based budgeting (PBB). Despite the institutionalization of these reforms, healthcare administrators continue to en...

Correlates of COVID-19 Vaccine Acceptance and Hesitancy in Rural Communities in Western Kenya

Abstract Vaccine hesitancy is a significant global public health concern. This study sought to determine the correlates of acceptance and hesitancy regarding COVID-19 vaccines in rural populations of selected counties in Western Kenya and assess the strategies that can be used to improve COVID-19 vaccine acceptance in Kenya. The study used a quantitative research strategy with a sample of 806 individuals in the Kisumu, Vihiga, and Kakamega counties. Descriptive statistics, correlations and r...

Prevalence of Non-Tuberculosis Mycobacterium Pulmonary Disease in HIV-1 Patients with Presumptive Pulmonary Tuberculosis in Western Kenya

Abstract Background: Non-tuberculous mycobacteria (NTMs) are ubiquitous, free-living, environmental saprophytic microorganisms. NTMs belong to the genus Mycobacterium which includes Mycobacterium tuberculosis (MTB). NTMs have lately been a major cause of pulmonary disease (PD) in immuno-compromised individuals including HIV-1 patients. NTMs and MTB appear similar based on microscopy, radiology, and clinical symptoms; consequently, this may lead to misdiagnosis. This study sought to establish...

Surveillance, preparedness and challenges of home-based care for COVID-19 patients and health workers in western Kenya

Abstract Study Objective(s): The main study objective was to report on surveillance data from, assess the preparedness and challenges of home-based care for COVID-19 patients and hhealth workers in four Counties (Kakamega, Vihiga, Bungoma, Busia) in Kenya. Design, setting and Participants: The study design and setting used was both qualitative and quantitative and it involved random sampling and snowballing sampling, to obtain data from health workers and patients in Home-Based Isolation. Pa...

Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Keny

Abstract Introduction: in Kenya, about 1.5 million people are living with the Human Immunodeficiency Virus (HIV). Antiretroviral therapy aids in viral suppression. However, drug-resistance threaten the gains of the HIV infection control program. To determine the prevalence of HIV-1 drug-resistant mutations among adults on ARV therapy attending Khunyangu sub-county hospital in Busia County, Kenya, 50 blood samples were analyzed. Methods: the samples were collected from November 2019 to Janua...

Correlation of HIV-1 drug resistant mutations and virologic failure

Abstract Introduction: mutations are important by ensuring that the HIV-1 agent remains fit in the environment and evades drugs that are developed purposely to kill them. In Kenya, mutations conferring resistance to available ARVs have been reported in previous studies. However, there is a paucity of information on whether these previous studies have reported all mutations conclusively that confer resistance to available drugs leading to virologic failure. Therefore, this study was sought to...

Supply Chain Information Systems and Service Delivery of the Public Health Care Sector in the County Governments of Western Region, Kenya

Abstract The healthcare sector has undergone significant changes within the past decades, and amidst these changes, attaining efficient and effective healthcare service delivery has remained a distant prospect. This study, therefore, sought to find out the effect of supply chain information systems on service delivery in the public health care sector in the county governments of the western region. The study was anchored on the theory of human service delivery and health network metrics. The...

Competence of Health Care Providers on Clinical Management of Myocardial Infarction in Selected Hospitals with Intensive Care Unit Western Kenya

Abstract Background: The capacity of healthcare providers to execute an accurate initial assessment is crucial for recognizing the urgency and treatment needs of patients and for creating baseline data from which any changes in patient status may be monitored. In Western Kenya, there is little evidence of studies carried out on the competence of healthcare providers in the clinical management of myocardial infractions thus this study's main aim was to investigate the competence of healthcare...

Moderating Effect of Organizational Culture on the Relationship between Quality of Work Life and Organizational Commitment Amongst Nurses in Public Hospitals in Bungoma County

Abstract Healthcare organisations are in dire need of a culture in which nursing employees are dedicated, motivated, and strongly associated with their sacred profession. This calls for strengthening the quality of the work life of nurses, which is an antecedent of organisational commitment. However, a number of studies that have explored the relationship between quality of work life and organisational commitment as moderated by organisational culture have been conducted in western countries...

Phytochemical, Cytotoxicity, and Antimycobacterial Activity Evaluation of Extracts and Compounds from the Stem Bark of Albizia coriaria Welw ex. Oliver

Abstract ackground. Albizia coriaria Welw ex. Oliver (Fabaceae) is one of the plants used by herbalists in the East Africa community to prepare herbal remedies for the management of symptoms of TB. Despite its widespread use, the antimycobacterial activity of this plant was uninvestigated and there was contradicting information regarding its cytotoxicity. Methods. Cytotoxicity (MTT), antimycobacterial activity (MABA), and phytochemical screening were conducted on crude extracts (hexane, chlo...

Sub-Acute Toxicity Effects of Methanolic Stem Bark Extract of Entada abyssinica on Biochemical, Haematological and Histopathological Parameters in Wistar Albino Rats

Abstract Background: Whereas the efficacy of Entada abyssinica (fabaceae) extracts against various ailments has been scientifically validated, its safety has not been established. This study was undertaken to evaluate the toxicity effects of methanolic stem bark extract of E. abyssinica on biochemical, haematological and histological parameters of Wistar albino rats following repeated oral administration. Methods: Wistar albino rats of both sexes were randomized into groups and orally admini...


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