Abstract Introduction Microbial infections are normally cited as a main environmental factor involved in pathology. The current study aimed at determining frequency of occurrence of pathogens in thyroid pathology.Our study is focused on human data. We have reviewed thyroid Fine Needle Aspiration (FNA) samples for pathogens. Methods Biopsy by fine-needle aspiration was applied in investigating the nodule for microbial involvement. Two smears were prepared on slides from each sample. The first...
Abstract m: In the present study, we investigated the prevalence of E. coli pathotypes and Shigella sero-groups and their antimicrobial profiles among diarrheic children in Nairobi city, Kenya. Background: Although diarrheagenic E. coli pathotypes and Shigella sero-groups are leading causes of diarrhea in children under five years in developing countries, their distribution and antimicrobial resistance vary from place to place and over time in a given region. Methods: In a cross-sectional st...
Abstract Background of the study: Early detection of the precursor lesion before the invasive stage of cervical cancer prevents further damage to the neighbouring tissues and organs. Bethesda system which applies cytological techniques is primarily used as a screening test while Richarts score is based on predicting the biological behaviour of abnormal epithelium. Laboratories in not so wellendowed settings should find the most predictive technique in assessing the cervical lesions. Objecti...
Abstract Dental caries manifests itself through the existence of a hole in the hard tissue of teeth, and it has a brown or black colour. Untreated dental caries causes a lot of challenges such as toothache and eventually tooth loss resulting in swelling, inability to eat or swallow, inability to open jaw or talk, difficulty in breathing and low self-esteem as a result of the bad breath from cavity. The outcome of the social effect of dental caries is the inability to pronounce or talk, inabi...
Abstract Background: Anopheles mosquitoes are the main malaria vector and as malaria cases decline in Sub Saharan Africa, there is a growing realisation that new interventions need to be added to complement the existing control strategies. To date, vector control is the most effective way to prevent malaria. Since the malaria parasite is maintained by mosquitoes which oviposit, feed and rest in the outdoor environment, there is an urgent need to focus on the control of oviposition sites seek...
Abstract Background World Health Organization recommend the use of malaria vaccine, Mosquirix, as a malaria prevention strategy. However, Mosquirix has failed to reduce the global burden of malaria because of its inefficacy. The Mosquirix vaccine’s modest effectiveness against malaria, 36% among kids aged 5 to 17 months who need at least four doses, fails to aid malaria eradication. Therefore, highly effective and efficacious malaria vaccines are required. The well-characterized P. falcipa...
Abstract This study on severe malarial anemia (SMA: Hb
Abstract The high incidence and prevalence of nosocomial pressure injuries pose a threat to safe hospitalization and additional strain on the healthcare system. Analysis of pressure injury risk factors is necessary for efficient prevention and management as part of the program to ensure that no patient experiences any preventable harm while receiving care, as per the international patient safety goals. This study evaluated the intrinsic and extrinsic risk factors for pressure injury among co...
Abstract Musculoskeletal pain (MSK) is a common and often distressing symptom among children diagnosed with sickle cell disease (SCD). Despite the recurrent and often severe pain episodes these children endure, there has been limited research into the factors that influence the management of this pain. This study sought to delve into the various factors that impact the management of MSK pain in children with SCD in Western Kenya. It took a comprehensive approach, considering psychological, e...
Abstract Context: Corona Virus Disease of 2019 (COVID-19), an infectious disease caused by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), spread across the globe, causing distress among various populations, including healthcare providers. This disease has had an unparalleled effect on the world's economic situation, livelihood, and mental and physical well-being across the globe. Aim: To assess the healthcare providers' psychological responses and related demographic and soc...
Abstract ineffective area of health system. In Kenya triage system is considered under developed and there is no National acceptable Accident and Emergency (A&E) triage system. Objective: The main objective of the study was to assess triage competency and its associated factors among healthcare providers in emergency department at selected hospitals in Kakamega County. Methods: This was a cross-sectional study design. Census sampling was used to select the General Practitioner hospitals. Sys...
Abstract Background and study aim: Hepatic derangements are emerging as prominent causes mortality and morbidity among HIV patients on Highly Active Antiretroviral therapy (HAART). Among this population, high HIV viremia, low CD4+ count and HAART have been established as risk factors for hepatic injury. Although HAART mitigates these risks, it is unknown whether non-adherence to it contributes to the development of hepatic derangements. The current study aimed at exploring whether non-adhere...
Abstract Context: The goal of triage is to prioritize patients who require the most urgent care and increase efficiency when resources are insufficient to treat all patients as per their degree or grade of injury. An effective and efficient emergency center triage system should be able to sort both trauma and non-trauma patients according to the level of acuity and involves treatment as per the physiological parameters, either coded as red, orange, yellow, green, or black. Kenyatta National ...
Abstract Background Although injection drug use drives antiretroviral drug resistance, the prevalence of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We, therefore, explored PI resistance mutations and their association with viral load and CD4+ T cell counts in HIV-1 infected IDUs (ART-naive, n = 32; and -experienced, n = 47) and non-drug users (ART-naive, n = 21; and -experienced, n = 32) naive for PI treatment from coastal Kenya. Results Only IDUs harboured ma...
Abstract Background The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is disseminated by respiratory aerosols. The virus uses the spike protein to target epithelial cells by binding to the ACE2 receptor on the host cells. As a result, effective vaccines must target the viral spike glycoprotein. However, the appearance of an Omicron variant with 32 mutations in its spike protein raises questions about the vaccine’s efficacy. Vacc...