Abstract/Overview Iron deficiency (ID) and human immunodeficiency virus (HIV) infection frequently coexist. Little data exist on ID in HIV-infected individuals, partly because the iron marker ferritin is altered by inflammation common in HIV infection. We measured iron biomarkers (ferritin, soluble transferrin receptor [sTfR], hepcidin) and red cell indices (hemoglobin, mean corpuscular volume [MCV]) in newly diagnosed, antiretroviral therapy-naive, HIV-infected (N = 138) and uninfected (...
Abstract/Overview Robert Shihuzire Magomere, , Tuberculosis (TB) is an infectious bacterial disease caused by bacillus Mycobacterium tuberculosis. Globally 9.6 million people fell ill with TB and 1.5 million died from the disease in 2014. Bumula Sub-County had 200 patients diagnosed with TB in 2016, with a case notification rate of 454 cases per 100,000 people. The main objective of this study was to establish the clinical and host related factors influencing prevalence of TB in Bumula Su...
Abstract/Overview Health workers competency is very critical in realization of quality health care which is a major pillar of Universal Health Coverage. This study assessed the influence of healthcare provider competency on Universal Health Coverage utilization in Seme Sub County, Kisumu County. The study targeted community households and health facility managers. The health facilities were stratified according to their tiers and randomly sampled. The catchment population was stratified b...
Abstract/Overview Despite the increase in the number of health services provided and Kenya’s commitment to equal access to quality healthcare for all by the year 2030, the physically challenged persons still find difficulty in accessing health services for reasons attributable to health care related factors. This study targeted the physically challenged persons in Gem Sub-county, Kenya. Stratified and systematic random sampling was used to select 108 people with physical disability. Dat...
Abstract/Overview In Kenya, approximately 3.3% to 4% of infants born annually are exposed to HIV due to lack of PMTCT interventions. Factors associated with mother – to – child HIV transmission as not been adequately investigated in Kenya. The study aim was to investigate factors associated with mother – to – child HIV transmission (MTCT) among HIV exposed infants in Siaya County. A retrospective cohort study design was adopted. Data involving 179 HIV exposed infants and their HIV...
Abstract/Overview Unmet need for contraception persists in Kenya despite an increase in awareness and availability of family planning services. There is a dearth of information on experiences and perceptions of contraception, specifically related to birth outcomes and menstruation patterns, in western Kenya. The aim of this study was to explore knowledge and perceptions on contraception, menstruation, and birth outcomes. In-depth interviews were conducted with 45 respondents; adolescent g...
Abstract/Overview In Kenya, no studies have attempted to model alternative scenarios of the cost-implications of reaching universal coverage (i.e. 95% population coverage) of the existing maternity health services network at the ward administrative level. A cross-sectional study design used publicly available geospatial data in combination with routine data from the web-based district health information software (DHIS2) platform. AccessMod (version 5) was used for scaling up analysis. Arc...
Abstract/Overview Background: Hepatocellular carcinoma (HCC) is a malignant cancer of the liver and a leading cause of cancer-related mortality worldwide. Human immunodeficiency virus (HIV) has not been known to have a direct causal relationship with HCC despite independently causing inflammation of the liver. However, little is known on risk factors for HCC patients in an HIV endemic area. The objective of this study was to ascertain the risk factors of HCC and its association with HIV i...
Abstract/Overview Globally, breast cancer incidence is on the rise, especially in developing countries and it is the most diagnosed cancer among women in Kenya. For the prevention and treatment, knowledge on early detection and risk factors is very important, however this has not been assessed among women of reproductive age attending Longisa County Referral Hospital Bomet County, Kenya. The study adopted a cross-sectional hospital based design to assess the knowledge on early detection a...
Abstract/Overview Tick-borne spotted fever group (SFG) rickettsioses are emerging human diseases caused by obligate intracellular Gram-negative bacteria of the genus Rickettsia. Despite being important causes of systemic febrile illnesses in travelers returning from sub-Saharan Africa, little is known about the reservoir hosts of these pathogens. We conducted surveys for rickettsiae in domestic animals and ticks in a rural setting in western Kenya. Of the 100 serum specimens tested from e...
Abstract/Overview Brucellosis is a common bacterial zoonotic infection but data on the prevalence among humans and animals is limited in Kenya. A cross-sectional survey was conducted in three counties practicing different livestock production systems to simultaneously assess the seroprevalence of, and risk factors for brucellosis among humans and their livestock (cattle, sheep, camels, and goats). A two-stage cluster sampling method with random selection of sublocations and households was...
Abstract/Overview We conducted serological surveys for Coxiella burnetii in archived sera from patients that visited a rural clinic in western Kenya from 2007 to 2008 and in cattle, sheep, and goats from the same area in 2009. We also conducted serological and polymerase chain reaction-based surveillance for the pathogen in 2009–2010, in human patients with acute lower respiratory illness, in ruminants following parturition, and in ticks collected from ruminants and domestic dogs. Antib...
Abstract/Overview The flea-borne rickettsioses murine typhus (Rickettsia typhi) and flea-borne spotted fever (FBSF) (Rickettsia felis) are febrile diseases distributed among humans worldwide. Murine typhus has been known to be endemic to Kenya since the 1950s, but FBSF was only recently documented in northeastern (2010) and western (2012) Kenya. To characterize the potential exposure of humans in Kenya to flea-borne rickettsioses, a total of 330 fleas (134 pools) including 5 species (Xeno...
Abstract/Overview Background Malaria epidemics in highland areas of East Africa have caused considerable morbidity and mortality in the past two decades. Knowledge of "hotspot" areas of high malaria incidence would allow for focused preventive interventions in resource-poor areas, particularly if the hotspot areas can be discerned during non-epidemic periods and predicted by ecological factors. Methods To address this issue, spatial distribution of malaria incidence and the relationship o...
Abstract/Overview There are many successful global health research partnerships, but little information is available about what makes them successful. We asked 14 research colleagues from Uganda, Kenya, and the United States who have extensive global health research experience about what they considered the top three factors that led to or impeded successful international research collaborations. Four key factors were identified: 1) mutual respect and benefit, 2) trust, 3) good communicat...