Abstract The first description of a disease resembling dengue fever (DF) was in the 15 century slave trade era by Spanish sailors visiting the Tanzania coast. The disease, then associated with evil spirits is now known to be caused by four serotypes of dengue virus (DENV1-4) that are transmitted by Aedes mosquitoes. Kenya has experienced multiple outbreaks, mostly associated with DENV-2. In this study, plasma samples obtained from 37 febrile patients during a DF outbreak at Kenya’s south c...
Abstract Introduction Despite documentation on injection drug use (IDU) in Kenya, the nutritional status of people who inject drugs (PWIDs) is under-explored. Elsewhere studies report under-nutrition among PWIDs which is attributed to food insecurity; competing priorities between drugs and food supply; chaotic lifestyle; reduced food intake; substance use induced malnutrition due to inflammation and comorbidities. Methods This was a cross-sectional study that sought to assess the nutritional...
Abstract Management of mentally ill patients is mainly done by psychiatric nurses in Kenya. This study sought to identify the association between nursing students’ psychiatric encounters and the perception towards psychiatric nursing in Kenya using a cross-sectional study design. Cluster and systematic random sampling were used to select the study participants. Data was analysed using SPSS version 21. Odds ratio was used to identify the association between variables. A significant associat...
Abstract Background Coxiella burnetii is a widely distributed pathogen, but data on its epidemiology in livestock, and human populations remain scanty, especially in developing countries such as Kenya. We used the One Health approach to estimate the seroprevalance of C. burnetii in cattle, sheep, goats and human populations in Tana River county, and in humans in Garissa county, Kenya. We also identified potential determinants of exposure among these hosts. Methods Data were collected through...
Abstract Primary Health Care (PHC) serves as the foundation for building a working healthcare system that provide good health outcomes. The quality of PHC delivery and the decision to refer patients depends on some behavioural factors (knowledge, skills and behaviour) of primary care providers. The study was conducted at 100 PHC centres sampled using Taro Yamane formula, in Machakos County, Kenya, from March to May 2015. It involved 8 gender-based focus group discussions (FGDs) with patients...
Abstract The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activit...
Abstract Ethnopharmacological relevance Medicinal plants play a major role in many communities across the world, in the treatment and prevention of disease and the promotion of general health. The aim of the study was to escalate documentation from an earlier study of medicinal plants, traditionally used to combat malaria by the Ameru community of Imenti Forest area and Gatunga in Eastern Region of Kenya, and validate their ethnopharmacological claims by evaluating their antiplasmodial effic...
Abstract Malaria is one of the most important parasitic diseases in the world. It remains a major public health problem in Africa and is responsible for the annual death of over one million children below the age of five years. The Plasmodium falciparum is the most widespread etiological agent for human malaria and has become increasingly resistant to standard antimalarial drugs. Therefore, this necessitates a continuous effort to search for new drugs, particularly with novel modes of action...
Abstract Introduction Microbial infections are normally cited as a main environmental factor involved in pathology. The current study aimed at determining frequency of occurrence of pathogens in thyroid pathology.Our study is focused on human data. We have reviewed thyroid Fine Needle Aspiration (FNA) samples for pathogens. Methods Biopsy by fine-needle aspiration was applied in investigating the nodule for microbial involvement. Two smears were prepared on slides from each sample. The first...
Abstract m: In the present study, we investigated the prevalence of E. coli pathotypes and Shigella sero-groups and their antimicrobial profiles among diarrheic children in Nairobi city, Kenya. Background: Although diarrheagenic E. coli pathotypes and Shigella sero-groups are leading causes of diarrhea in children under five years in developing countries, their distribution and antimicrobial resistance vary from place to place and over time in a given region. Methods: In a cross-sectional st...
Abstract Background of the study: Early detection of the precursor lesion before the invasive stage of cervical cancer prevents further damage to the neighbouring tissues and organs. Bethesda system which applies cytological techniques is primarily used as a screening test while Richarts score is based on predicting the biological behaviour of abnormal epithelium. Laboratories in not so wellendowed settings should find the most predictive technique in assessing the cervical lesions. Objecti...
Abstract Dental caries manifests itself through the existence of a hole in the hard tissue of teeth, and it has a brown or black colour. Untreated dental caries causes a lot of challenges such as toothache and eventually tooth loss resulting in swelling, inability to eat or swallow, inability to open jaw or talk, difficulty in breathing and low self-esteem as a result of the bad breath from cavity. The outcome of the social effect of dental caries is the inability to pronounce or talk, inabi...
Abstract Background: Anopheles mosquitoes are the main malaria vector and as malaria cases decline in Sub Saharan Africa, there is a growing realisation that new interventions need to be added to complement the existing control strategies. To date, vector control is the most effective way to prevent malaria. Since the malaria parasite is maintained by mosquitoes which oviposit, feed and rest in the outdoor environment, there is an urgent need to focus on the control of oviposition sites seek...
Abstract Background World Health Organization recommend the use of malaria vaccine, Mosquirix, as a malaria prevention strategy. However, Mosquirix has failed to reduce the global burden of malaria because of its inefficacy. The Mosquirix vaccine’s modest effectiveness against malaria, 36% among kids aged 5 to 17 months who need at least four doses, fails to aid malaria eradication. Therefore, highly effective and efficacious malaria vaccines are required. The well-characterized P. falcipa...
Abstract This study on severe malarial anemia (SMA: Hb