ABSTRACT Effect of stabilizing chloroquine phosphate in a synthetic Aluminium Magnesium silicate (Nanoparticles) on the antiplasmodial activity of the drug was investigated. Mice infected with Plasmodium berghei were treated with chloroquine phosphate at 7 mg/kg, 5 mg/kg and 3 mg/kg dose levels respectively. Two subgroups at each dose level were treated with chloroquine phosphate alone and with a drug formulation of 20% chloroquine phosphate in the synthetic Aluminium Magnesium Silicate (AMS...
ABSTRACT Controlled release floating metformin hydrochloride microbeads were prepared and optimized using a blend of varying concentrations of freeze-dried pregelatinized Chinese yam starch (Dioscorea oppositifolia L) and sodium alginate. Floating microbeads were prepared by the ionotropic gelation method using 10% w/v calcium chloride as the cross-linking agent and sodium bicarbonate as the gas releasing agent. A full 32 factorial design was used to investigate the influence of two variables...
ABSTRACT Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. It is a growing public health concern worldwide affecting humans and animals. Synthetic drugs available for the treatment of the ailment have serious side effects, complicated mode of intake and are costly. Literature search revealed that Cussonia arborea is used folklorically in the management of Diabetes mellitus....
ABSTRACT Fifteen dogs of similar age (8-12 months) were used for the clinical study. They were randomized into 3 groups (CH1-5, CL1-5 AND AC1-5). Simple transverse femoral fractures were created under anaesthesia using a bone saw. Spatial alignment of the bone was achieved by insertion of an intramedullary pin. Radiographic assessment confirmed that the pins were intact and internal fixation was thorough. Celecoxib (Celebrex® Pfizer Inc, Germany) was supplied in encapsulated powdered form a...
ABSTRACT The toxicology of six suspected poisonous plants Leucaena leucocephala Benth, Tribulus terrestris Linn Eugenia uniflora Linn, Dichapetalum madagascasience Poir, Lantana camara Linn, and Solanum torvum Benth); were evaluated in Sprague Dawley rats weighing between 200-300 grams. Two of these plants, Lantana camara and ~. madagascasience were re-evaluated in West African dwarf goats. Spectrophotometric and titrimetric methods were also used to determine some inorganic and metallic cont...
ABSTRACT This study was carried out to evaluate the chemical composition and bacterial load of donkey meat as well as the prevalence of verotoxigenic Escherichia coli (VTEC). The study adopted the survey and experimental designs. A questionnaire, which comprised three sections, was developed to elicit information on the demographics, source of meat, and factors that influence choice of meat consumed by the respondents. The instrument for data collection was validated by three experts. A pilo...
ABSTRACT Nigeria has an annual population growth rate of 2.6 and a relatively high Total Fertility Rate (TFR) of 5.6 due to its larger family size. Men‟s fertility desire is a strong determinant of family sizes, but it is women that perform greater share of childcare activities. The potential relationship between the desire for childbearing and the responsibility of early childcare between spouses has not been adequately explored. This study was therefore designed to determine the extent to...
ABSTRACT The contractile activity of M. pruriens and the relaxatory property of C. odorata was investigated using in vitro methods in the rat. M. pruriens caused a dose-dependent increase in uterine muscle contraction with a maximum peak in amplitude with 0.57 mg/ml of the extract and an EC50 of 2.7 mg/ml. The contraction was unaffected by atropine sulphate (0.042 µmol), but abolished by isoprenaline (0.06-0.23 µmol), salbutamol (0.012-0.4 µmol) and adrenaline (16 nmol).Uterine muscle con...
ABSTRACT The purpose of this study was to identify the factors that affect clinical training of nursing students in School of Nursing Afikpo in Ebonyi State and Department of Nursing Sciences, University of Nigeria, Enugu Campus in Enugu State. Four research questions and three null hypotheses guided the study. The research design used was descriptive cross-sectional survey method. A face and content validated questionnaire with 34 items was used for the collection of data. Data derived from...
ABSTRACT The effect of PGE^, P5P?a and PGI0 on tilu lion induced by different mechanisms was studied in the isolated rat mesenteric arteiy as described by McGregor (1965) Vasoconstriction was induced by mechanisms involving dii modes of calcium utilization viz: (i) Pharmaccnechanical pathway by low doses of the adrenergic neurotransm.itter, noradrenaline acting at - receptor; (ii) electromechanical pathway by 1.1 b potassium-and” (iip.) agents which facilitate Ca influx e.g. A23187. ! The p...
ABSTRACT The fusion between the “breakpoint cluster region” gene (BCR) and Abelson gene (ABL1) is the molecular hallmark of most cases of chronic myeloid leukaemia and some cases of acute lymphoblastic leukaemia. The objective of this study was to detect BCR-ABL1 in saliva of known CML patients collected in Oragene-RNA kit (DNA Genotek, Canada) and to see if mRNA could be preserved for a longer period in the saliva samples than in blood samples. A comparison of the BCR-ABL ratios in bloo...
ABSTRACT Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered through the oral route. Rectal administration, which formed the basis of this work, is an alternative route of administration which overcomes the lim...
ABSTRACT Involving men in Maternal Health Care (MHC) has become important because of the realization that men‟s behaviour can significantly affect health outcomes of women and children. Male involvement in MHC is generally poor in many developing countries including Nigeria. Reasons for poor male involvement in MHC services have not been adequately documented. This study was therefore designed to determine hindrances to male involvement in MHC in Kwali Area Council, Abuja, Nigeria. A commun...
ABSTRACT The prognostic significance of asymptomatic bacteriuria resides in the observation that the prevalence is, relatively, high in persons with certain medical conditions, such as diabetes mellitus and pregnancy. This prevalence might, even, be higher in patients with human immunodeficiency virus infection. Hence, this study set out to determine the prevalence of asymptomatic bacteriuria among symptom free and newly enrolled HIV infected pregnant women attending PMTCT unit of Antiretrovi...
ABSTRACT Pregelatinized Chinese yam (Dioscorea oppositifolia) starch has been evaluated as a polymer for the formulation of floating gastroretentive beads for the controlled delivery of metformin hydrochloride. Floating microbeads were prepared by the ionotropic gelation method using a blend of modified Chinese yam starch and sodium alginate at different ratios. Sodium bicarbonate was added as a gas-generating agent. The floating microbeads were characterized by SEM, DSC, FTIR analyses and...